Mitotic Spindle Checkpoints

Known as: Mitotic Spindle Checkpoint, Checkpoints, Mitotic Spindle, Spindle Checkpoint, Mitotic 
A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
The mitotic arrest-deficient protein Mad1 forms a complex with Mad2, which is required for imposing mitotic arrest on cells in… (More)
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Highly Cited
2005
Highly Cited
2005
Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show… (More)
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Highly Cited
2002
Highly Cited
2002
The E2F transcription factor family is known to play a key role in the timely expression of genes required for cell cycle… (More)
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Highly Cited
2001
Highly Cited
2001
We discovered that many proteins located in the kinetochore outer domain, but not the inner core, are depleted from kinetochores… (More)
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Highly Cited
2001
Highly Cited
2001
The ability of kinetochores to recruit microtubules, generate force, and activate the mitotic spindle checkpoint may all depend… (More)
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Highly Cited
2001
Highly Cited
2001
In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near the spindle equator after anaphase… (More)
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Highly Cited
2000
Highly Cited
2000
Bub3 is a conserved component of the mitotic spindle assembly complex. The protein is essential for early development in Bub3… (More)
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Highly Cited
1999
Highly Cited
1999
Aneuploidy is a characteristic of the majority of human cancers, and recent work has suggested that mitotic checkpoint defects… (More)
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Highly Cited
1998
Highly Cited
1998
Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes… (More)
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Highly Cited
1995
Highly Cited
1995
p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been… (More)
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