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Mitotic Spindle Checkpoints

Known as: Mitotic Spindle Checkpoint, Checkpoints, Mitotic Spindle, Spindle Checkpoint, Mitotic 
A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the… 
National Institutes of Health

Related topics

Related topics

36 relations
BUB1 geneBUB1 protein, humanBUB1 wt AlleleBUB1B gene

Broader (3)

M Phase Cell Cycle CheckpointsMitotic Cell Cyclespindle checkpoint activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.
Active cyclin B1-Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the… 
2010
2010
MAP kinase regulation of the mitotic spindle checkpoint.
Maintaining the integrity of the cell cycle is critical for ensuring that cells only undergo DNA replication and proliferation… 
Highly Cited
2009
Highly Cited
2009
PF-00477736 Mediates Checkpoint Kinase 1 Signaling Pathway and Potentiates Docetaxel-Induced Efficacy in Xenografts
Purpose: Checkpoint kinase 1 (Chk1) plays a critical role in the activation of mitotic spindle checkpoint and DNA damage… 
2006
2006
Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway.
Highly Cited
2005
Highly Cited
2005
The Mitotic Spindle Checkpoint Is a Critical Determinant for Topoisomerase-based Chemotherapy*
A novel strategy in cancer therapy is the induction of mitotic cell death by the pharmacological abrogation of cell cycle… 
Highly Cited
2005
Highly Cited
2005
The role of Cdc55 in the spindle checkpoint is through regulation of mitotic exit in Saccharomyces cerevisiae.
Cdc55, a B-type regulatory subunit of protein phosphatase 2A, has been implicated in mitotic spindle checkpoint activity and… 
2005
2005
Aneuploidy-Cancer Predisposition Syndromes: A New Link between the Mitotic Spindle Checkpoint and Cancer
Genetic cancer predisposition syndromes have been crucial to the identification of genes and pathways involved in carcinogenesis… 
2003
2003
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T
To determine sequence variations of the BUB1 and BUB1B genes in pancreatic cancer, the entire coding regions of the BUB1 and… 
2000
2000
Bub 3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
Bub3 is a conserved component of the mitotic spindle assembly complex. The protein is essential for early development in Bub3… 
1999
1999
Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations.
Ataxia telangiectasia (AT) carrier-derived lymphoblastoid cell lines (AT-LCLs/hetero) with suboptimal ATM protein expression were… 
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