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Mitotic Spindle Checkpoints

Known as: Mitotic Spindle Checkpoint, Checkpoints, Mitotic Spindle, Spindle Checkpoint, Mitotic 
A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the… 
National Institutes of Health

Related topics

Related topics

36 relations
BUB1 geneBUB1 protein, humanBUB1 wt AlleleBUB1B gene

Broader (3)

M Phase Cell Cycle CheckpointsMitotic Cell Cyclespindle checkpoint activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
MAP kinase regulation of the mitotic spindle checkpoint.
Maintaining the integrity of the cell cycle is critical for ensuring that cells only undergo DNA replication and proliferation… 
2006
2006
Characterization of Drosophila Rad51/SpnA protein in DNA binding and embryonic development.
2006
2006
Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice
Dysregulated expression of the homeobox gene, HOX11 is a frequent etiologic event in T-cell acute lymphoblastic leukemias. HOX11… 
Highly Cited
2005
Highly Cited
2005
The Mitotic Spindle Checkpoint Is a Critical Determinant for Topoisomerase-based Chemotherapy*
A novel strategy in cancer therapy is the induction of mitotic cell death by the pharmacological abrogation of cell cycle… 
Review
2005
Review
2005
Newly identified roles for an old guardian: Profound deficiency of the mitotic spindle checkpoint protein BubR1 leads to early aging and infertility
The mitotic spindle checkpoint ensures proper chromosome segregation, and thereby guards against the deleterious effects of… 
2003
2003
Loss of Mitotic Spindle Checkpoint Activity Predisposes to Chromosomal Instability at Early Stages of Fibrosarcoma Development
Mice carrying the bovine papillomavirus type I genome develop dermal fibrosarcomas in a multiple step process characterized by… 
2000
2000
Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.
Genomic instability is observed in the majority of human tumors. Dysregulation of the mitotic spindle checkpoint is thought to be… 
1999
1999
Defective control of apoptosis and mitotic spindle checkpoint in heterozygous carriers of ATM mutations.
Ataxia telangiectasia (AT) carrier-derived lymphoblastoid cell lines (AT-LCLs/hetero) with suboptimal ATM protein expression were… 
1999
1999
p 53 regulates a G 2 checkpoint through cyclin B 1 ( cell cycle y cdc 2 y mitosis y cancer )
The p53 tumor suppressor controls multiple cell cycle checkpoints regulating the mammalian response to DNA damage. To identify… 
1995
1995
Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons.
The presence of centromeric DNA was studied in micronuclei isolated from the blood of male ddY mice after five weekly… 
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