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BUB1 gene

Known as: BUB1 mitotic checkpoint serine/threonine kinase, BUB1 Mitotic Checkpoint Serine/Threonine Kinase Gene, BUB1, S. CEREVISIAE, HOMOLOG OF 
This gene is a modulator of the mitotic spindle cell cycle checkpoint.
National Institutes of Health

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13 relations
BUB1 protein, humanBUB1B geneBUB1B wt AlleleColon Carcinoma

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BUB1 wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
The physiological role of the mitotic checkpoint protein Bub1 is unknown. To study this role, we generated a series of mutant… 
Highly Cited
2007
Highly Cited
2007
BUB1 mediation of caspase-independent mitotic death determines cell fate
The spindle checkpoint that monitors kinetochore–microtubule attachment has been implicated in tumorigenesis; however, the… 
Highly Cited
2004
Highly Cited
2004
Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1.
The mitotic spindle checkpoint protein Bub1 has been found to be mutated at low frequency in certain human cancers characterized… 
Highly Cited
2004
Highly Cited
2004
Phosphorylation and activation of Bub1 on unattached chromosomes facilitate the spindle checkpoint
The spindle checkpoint inhibits anaphase until all kinetochores have attached properly to spindle microtubules. The protein… 
Highly Cited
2004
Highly Cited
2004
Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells
The spindle assembly checkpoint detects errors in kinetochore attachment to the spindle including insufficient microtubule… 
Highly Cited
2002
Highly Cited
2002
Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma
Chromosomal instability (CI) leading to aneuploidy is one form of genetic instability, a characteristic feature of various types… 
Highly Cited
2001
Highly Cited
2001
The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions
Centromere function requires the coordination of many processes including kinetochore assembly, sister chromatid cohesion… 
Highly Cited
2001
Highly Cited
2001
Spindle Checkpoint Protein Bub1 Is Required for Kinetochore Localization of Mad1, Mad2, Bub3, and Cenp-E, Independently of Its Kinase Activity
The spindle checkpoint inhibits the metaphase to anaphase transition until all the chromosomes are properly attached to the… 
Highly Cited
2001
Highly Cited
2001
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.
BUB1 is a budding yeast gene required to ensure that progression through mitosis is coupled to correct spindle assembly. Two… 
Highly Cited
1994
Highly Cited
1994
The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase.
Normal cell multiplication requires that the events of mitosis occur in a carefully ordered fashion. Cells employ checkpoints to… 
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