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BUB1 gene

Known as: BUB1 mitotic checkpoint serine/threonine kinase, BUB1 Mitotic Checkpoint Serine/Threonine Kinase Gene, BUB1, S. CEREVISIAE, HOMOLOG OF 
This gene is a modulator of the mitotic spindle cell cycle checkpoint.
National Institutes of Health

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13 relations
BUB1 protein, humanBUB1B geneBUB1B wt AlleleColon Carcinoma

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BUB1 wt Allele

Papers overview

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2019
2019
Serine/threonine kinase BUB1 promotes proliferation and radio-resistance in glioblastoma.
2009
2009
TAp73α binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy
Aneuploidy is a characteristic of most solid tumors, often associated with negative prognosis. It can arise from two principal… 
Highly Cited
2003
Highly Cited
2003
Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts.
The relative contribution of aneuploidy and gene mutations to human tumorigenesis is not yet known. Studies in mice have… 
2003
2003
A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T
To determine sequence variations of the BUB1 and BUB1B genes in pancreatic cancer, the entire coding regions of the BUB1 and… 
2002
2002
Expression of hBUB1 in Acute Myeloid Leukemia
hBUB1 gene is a component of the mitotic checkpoint that monitors proper assembly of the mitotic spindles and the alteration of… 
2000
2000
Pericentromeric regions containing 1.688 satellite DNA sequences show anti-kinetochore antibody staining in prometaphase chromosomes of Drosophila melanogaster
Abstract. A striking characteristic of the centromeric heterochromatin of Drosophila melanogaster is that each chromosome carries… 
Highly Cited
2000
Highly Cited
2000
Infrequent Mutation of the hBUB1 and hBUBR1 Genes in Human Lung Cancer
Mitotic checkpoint defects of the cell cycle have been implicated in the development of human cancers. Since hBUB1 and hBUBR1… 
2000
2000
Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer.
Genomic instability is observed in the majority of human tumors. Dysregulation of the mitotic spindle checkpoint is thought to be… 
2000
2000
Differential spindle assembly checkpoint response in human lung adenocarcinoma cells
Abstract. CI-980 is an antimicrotubule agent that binds the colchicine site on tubulin. We examined CI-980 cytotoxicity in two… 
1997
1997
Mammalian BUB1 protein kinases: map positions and in vivo expression.
The spindle assembly checkpoint modulates the timing of anaphase initiation in mitotic cells containing improperly aligned… 
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