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Losartan

Known as: lozartan, Losartan [Chemical/Ingredient], 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol 
The potassium salt form of losartan, a non-peptide angiotensin II antagonist with antihypertensive activity. Losartan potassium selectively and… 
National Institutes of Health

Related topics

Related topics

36 relations
Angiotensin 2 Receptor Antagonists [MoA]Angiotensin 2 Type 1 Receptor Antagonists [MoA]Congestive heart failureDecreased Blood Pressure [PE]

Broader (7)

Angiotensin II Type 1 Receptor BlockersAngiotensin Receptor AntagonistsAnti-Arrhythmia AgentsAntihypertensive Agents

Narrower (7)

CozaarDuP-753HM70186Hyzaar

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
BDDCS Applied to Over 900 Drugs
Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS) classification for 927 drugs, which include… 
Highly Cited
2007
Highly Cited
2007
Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency.
The Renoprotection of Optimal Antiproteinuric Doses (ROAD) study was performed to determine whether titration of benazepril or… 
Highly Cited
2003
Highly Cited
2003
RETRACTED: Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial
Highly Cited
2003
Highly Cited
2003
Regression of Electrocardiographic Left Ventricular Hypertrophy by Losartan Versus Atenolol: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) Study
Background—Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and… 
Highly Cited
2000
Highly Cited
2000
Angiotensin II induces contraction and proliferation of human hepatic stellate cells.
Highly Cited
2000
Highly Cited
2000
Inhibition of early atherogenesis by losartan in monkeys with diet-induced hypercholesterolemia.
BACKGROUND Angiotensin II may contribute to atherogenesis by facilitating the proliferative and inflammatory response to… 
Highly Cited
1999
Highly Cited
1999
Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-/NADPH-oxidases.
Highly Cited
1993
Highly Cited
1993
Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
Highly Cited
1990
Highly Cited
1990
Subclasses of angiotensin II binding sites and their functional significance.
Specific binding sites for angiotensin II were identified in the rabbit adrenal gland and uterus and in the rat liver and were… 
Highly Cited
1990
Highly Cited
1990
Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.
This report describes the pharmacology of (2-n-butyl-4-chloro-1- [(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5… 
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