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Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis.
The prophylactic and therapeutic potentials, possible molecular mechanism for the antagonism of angiotensin II receptors on the changes in the severity of pancreatic injury induced by acute pancreatitis, and the protective role of AT(1) receptor antagonist, losartan, could be mediated by the inhibition of NAD(P)H oxidase-dependent generation of reactive oxygen species (ROS). Expand
Rhein, a Natural Anthraquinone Derivative, Attenuates the Activation of Pancreatic Stellate Cells and Ameliorates Pancreatic Fibrosis in Mice with Experimental Chronic Pancreatitis
It is reported that rhein attenuates PSC activation and suppresses SHH/GLI1 signaling in pancreatic fibrosis and can be a potential remedy for fibrotic and/or PSC-related pathologies in the pancreas. Expand
Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis
- S. Tsang, Y. Guan, Juan Wang, Z. Bian, Hong-Jie Zhang
- Medicine, Chemistry
- Scientific reports
- 14 March 2016
Upon the oral administration of dihydro-resveratrol, the severity of acute pancreatitis in the cerulein-treated rats was significantly ameliorated as evidenced by decreased α-amylase activities in the plasma and lessened oedema formation in the pancreatic parenchyma. Expand
Nerve growth factor‐mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation‐induced visceral hypersensitivity in rats
The data strongly suggest that NGF triggers neuronal plasticity and plays a crucial role in NMS‐induced visceral hypersensitivity in which NGF antagonism provides positive inhibition via blocking the tyrosine phosphorylation of TrkA. Expand
A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn.
- Hai-tao Xiao, S. Tsang, +8 authors Z. Bian
- Chemistry, Medicine
- Journal of ethnopharmacology
- 16 September 2013
Evidence is provided of the utilization of Polygonum chinense L. for diarrhea, and ellagic acid and corilagin are two components contributing to the anti-diarrheal effect. Expand
Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis.
- Hai-tao Xiao, Cheng-yuan Lin, +7 authors Z. Bian
- Chemistry, Medicine
- Journal of natural products
- 7 November 2013
It is demonstrated that corilagin exerts a protective effect on DSS-induced colitis, and its underlying mechanisms are associated with inhibition of the NF-κB pathway that mitigates colon inflammatory responses and apoptosis of intestinal epithelial cells. Expand
Differential effects of saralasin and ramiprilat, the inhibitors of renin–angiotensin system, on cerulein-induced acute pancreatitis
Results indicate that administration of saralasin but not ramiprilat could be protective against acute pancreatitis and that activation of pancreatic RAS in acute Pancreasitis may play a role in pancreatic tissue injury. Expand
Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings.
- Hai-tao Xiao, Linda Li-dan Zhong, S. Tsang, Ze-si Lin, Z. Bian
- The American journal of Chinese medicine
- 16 February 2015
Traditional Chinese Medicine formulas appear to be promising for IBS treatment, based on the clinical randomized controlled trials conducted in the literature from 1998 to September 2013. Expand
Eruberin A, a Natural Flavanol Glycoside, Exerts Anti-Fibrotic Action on Pancreatic Stellate Cells
- S. Tsang, Hong-Jie Zhang, Ye-Gao Chen, K. Auyeung, Z. Bian
- Medicine, Biology
- Cellular Physiology and Biochemistry
- 27 July 2015
Eruberin A significantly suppressed the expression levels of fibrotic mediators in PSCs, and it is suggested that its anti-fibrotic mechanism was associated with an attenuation of the PI3K/AKT/NF-κB signaling pathway. Expand
Dihydro‐Resveratrol Ameliorates Lung Injury in Rats with Cerulein‐Induced Acute Pancreatitis
This study is the first to report the oral administration of dihydro‐resveratrol ameliorated acute pancreatitis‐associated lung injury via an inhibitory modulation of pro‐inflammatory response, which was associated with a suppression of the NF‐κB signaling pathway. Expand