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DuP-753

Known as: DuP 753, DuP753 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

LosartanLosartan Potassium

Papers overview

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Highly Cited
2000
Highly Cited
2000
Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms.
Nuclear factor-kappaB (NF-kappaB) regulates many genes involved in vascular physiopathology. We have previously observed in vivo… 
Highly Cited
1994
Highly Cited
1994
Angiotensin II receptor binding following myocardial infarction in the rat.
OBJECTIVE The aim was to determine angiotensin II receptor binding and its relationship to angiotensin converting enzyme (ACE… 
Highly Cited
1993
Highly Cited
1993
Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.
Aspartic acid in the second transmembrane domain is a highly conserved amino acid among the G protein-coupled receptors and is… 
Highly Cited
1993
Highly Cited
1993
Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion.
Excessive secretion of aldosterone from the adrenal results in the most common form of endocrine hypertension. An understanding… 
Highly Cited
1993
Highly Cited
1993
Angiotensin II(3–8) (ANG IV) hippocampal binding: Potential role in the facilitation of memory
Highly Cited
1993
Highly Cited
1993
6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.
Starting from the recently reported nonpeptidic angiotensin II (AII) receptor antagonists DuP753 (1) and Exp 7711 (2), we have… 
Highly Cited
1992
Highly Cited
1992
Regulation of the expression of the rat angiotensin II receptor mRNA.
Highly Cited
1991
Highly Cited
1991
Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.
Both neurons and astrocytes contain specific receptors for angiotensin II (AII). We used selective ligands for the AT1 and AT2… 
Highly Cited
1991
Highly Cited
1991
Angiotensin II receptor subtypes in rat brain and peripheral tissues.
Angiotensin II (Ang II) receptor binding was localized in rat adrenal gland, kidney, and brain by in vitro autoradiography using… 
Highly Cited
1990
Highly Cited
1990
Two angiotensin II binding sites in rat brain revealed using [125I]Sar1, Ile8-angiotensin II and selective nonpeptide antagonists.
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