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DuP-753

Known as: DuP 753, DuP753 
National Institutes of Health

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2 relations

Broader (2)

LosartanLosartan Potassium

Papers overview

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2010
2010
Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI.
GPVI is a key receptor for collagen-induced platelet activation. Loss or inhibition of GPVI causes only mildly prolonged bleeding… 
1996
1996
The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteins.
We examined the effects of angiotensin II (Ang II) and its analogue CGP42112 on cell growth through the Ang II type 2 receptor… 
1994
1994
Activation of AT1 angiotensin receptors induces DNA synthesis in a rat intestinal epithelial (RIE-1) cell line.
Proliferation of the rat intestinal epithelial cell-line, RIE-1, has previously been shown to be stimulated by certain… 
1994
1994
Comparative pharmacology of recombinant rat AT1A, AT1B and human AT1 receptors expressed by transfected COS‐M6 cells
1 Currently available antagonists and agonists cannot distinguish between angiotensin AT1 receptor subtypes. 2 We synthesized a… 
1993
1993
Angiotensin converting enzyme inhibitors or DuP753 prevent neointimal formation following balloon injury with single topical or multiple systemic application.
Angiotensin II plays an important role in neointimal formation after vascular injury. Our objectives were 1) to investigate the… 
1993
1993
Angiotensin II stimulates increased protein synthesis, not increased DNA synthesis, in intact rat aortic segments, in vitro.
There is considerable controversy regarding whether angiotensin II (AngII) stimulates hypertrophy or hyperplasia of vascular… 
1992
1992
Angiotensin II stimulation of plasminogen activator inhibitor-1 gene expression in astroglial cells from the brain.
In this study, we investigated the mechanism of angiotensin II (Ang II) induced secretion of plasminogen activator inhibitor-1… 
1992
1992
Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive…
In aggregate cell cultures of 15- to 20-day-old rat pituitary maintained in serum-free medium, luteinizing hormone-releasing… 
1991
1991
ANGIOTENSIN II RECEPTOR SUBTYPES IN RAT BRAIN
1. Angiotensin II (AII) receptor binding was localized in the rat brain by in vitro autoradiography using the antagonist analogue… 
Highly Cited
1990
Highly Cited
1990
Two angiotensin II binding sites in rat brain revealed using [125I]Sar1, Ile8-angiotensin II and selective nonpeptide antagonists.
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