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Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer?
View on Elsevier
Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid Atherosclerosis: Principal Results of the European Lacidipine Study on Atherosclerosis (ELSA), a Randomized, Double-Blind,…
TLDR
The greater efficacy of lacidipine on carotid IMT progression and number of plaques per patient, despite a smaller ambulatory blood pressure reduction, indicates an antiatherosclerotic action of lacIDipine independent of its antihypertensive action.
View on Wolters Kluwer
Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium.
TLDR
O2- generation is increased in SHRSP and that the tissue and enzymatic sources of this excess O2- appear to be the endothelium and eNOS, respectively.
View on PubMed
Endothelin-1-Induced Reductions in Cerebral Blood Flow: Dose Dependency, Time Course, and Neuropathological Consequences
TLDR
It is demonstrated that endothelin-1 is capable of reducing blood flow to pathologically low levels and provide a new model of controlled focal ischaemia followed by reperfusion.
View on SAGE
A species difference in the presystemic metabolism of carbazeran in dog and man.
TLDR
The lack of detectable pharmacological effect in man following oral administration of the carbazeran appears to be due to presystemic metabolism by a particularly active pathway not found in the dog.
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Technical report: quantitative assessment of diaphragmatic movement--a reproducible method using ultrasound.
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The sympathetic nervous system and the metabolic syndrome.
TLDR
The behaviour of the sympathetic nervous system in the metabolic syndrome as well as the mechanisms potentially responsible for this neurogenic abnormality are examined.
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Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus
TLDR
This investigation was designed to identify the genetic component responsible for large infarct volumes in theSHRSP in response to a focal ischaemic insult by performance of a genome scan in an F2 cross derived from the SHRSP and the normotensive reference strain, WKY rat.
View on Nature
The metabolism and kinetics of doxazosin in man, mouse, rat and dog.
TLDR
Comparison of the oral and intravenous data show that doxazosin is completely absorbed in man, mouse and rat and is moderately well absorbed in dog, whereas the drug is extensively metabolized in man and only about 5% of the dose was excreted unchanged in man.
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Risk factors associated with alterations in carotid intima—media thickness in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis
TLDR
Analysis of baseline data from the ELSA has shown that there is an extremely marked prevalence of carotid artery wall alterations among mild-to-moderate, middle-aged hypertensive patients, and significant correlations between ultrasound measurements and the following demographic and clinical variables.
View on Wolters Kluwer
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