Levodopa

Known as: beta-(3,4-Dihydroxyphenyl)-L-alanine, 3,4-Dihydroxy-L-phenylalanine, .beta.-(3,4-Dihydroxyphenyl)-L-alanine 
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1938-2017
050019382016

Related topics

Related topics

37 relations

Narrower (21)

2,4,5-trihydroxyphenylalanine quinone2,4-dihydroxyphenylalanine3,4,6-trihydroxyphenylalanine quinone3-O-methyl-6-fluoro-dopa
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Broader (3)

Amino AcidsAntiparkinson AgentsDopa
Carbidopa 10 MG / Levodopa 100 MG Oral TabletCarbidopa 10 MG / Levodopa 100 MG Oral Tablet [Sinemet]Carbidopa 25 MG / Levodopa 100 MG Disintegrating Oral TabletCarbidopa 25 MG / entacapone 200 MG / Levodopa 100 MG Oral Tablet
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Levodopa
Amino Acids
Parkinson Disease
Dopa
Methyldopa
Antiparkinson Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Parkinson disease
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age… (More)
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Review
2015
Review
2015
Parkinsonism in Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) presents heterogeneous clinical phenotypes, and parkinsonism is reported in diverse SCA subtypes… (More)
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Highly Cited
2006
Highly Cited
2006
Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
Theories of instrumental learning are centred on understanding how success and failure are used to improve future decisions… (More)
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Highly Cited
2003
Highly Cited
2003
Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study.
Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot… (More)
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Highly Cited
2002
Highly Cited
2002
Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression.
  • JAMA
  • 2002
CONTEXT Pramipexole and levodopa are effective medications to treat motor symptoms of early Parkinson disease (PD). In vitro and… (More)
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Highly Cited
2001
Highly Cited
2001
Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa.
Event-related functional MRI (fMRI) was used to study blood oxygen level dependent cortical signal changes associated with… (More)
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Highly Cited
2000
Highly Cited
2000
A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa.
BACKGROUND There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a… (More)
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Highly Cited
2000
Highly Cited
2000
Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies… (More)
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Highly Cited
1996
Highly Cited
1996
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… (More)
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Highly Cited
1979
Highly Cited
1979
Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey.
Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed… (More)
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