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Levodopa
Known as:
beta-(3,4-Dihydroxyphenyl)-L-alanine
, 3,4-Dihydroxy-L-phenylalanine
, .beta.-(3,4-Dihydroxyphenyl)-L-alanine
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An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and…
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National Institutes of Health
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Related topics
Related topics
37 relations
Narrower (19)
2,4,5-trihydroxyphenylalanine quinone
2,4-dihydroxyphenylalanine
3,4,6-trihydroxyphenylalanine quinone
3-O-methyl-6-fluoro-dopa
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Broader (2)
Antiparkinson Agents
Dopa
Carbidopa 10 MG / Levodopa 100 MG Disintegrating Oral Tablet
Carbidopa 10 MG / Levodopa 100 MG Oral Tablet
Carbidopa 10 MG / Levodopa 100 MG Oral Tablet [Sinemet]
Carbidopa 25 MG / Levodopa 100 MG Disintegrating Oral Tablet
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study
A. Whone
,
R. Watts
,
+10 authors
D. Brooks
Annals of neurology
2003
Corpus ID: 25105795
Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot…
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Highly Cited
2002
Highly Cited
2002
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
V. Bonifati
,
P. Rizzu
,
+15 authors
P. Heutink
Science
2002
Corpus ID: 27186691
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a…
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Highly Cited
2001
Highly Cited
2001
Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literature
J. Ahlskog
,
M. Muenter
Movement disorders : official journal of the…
2001
Corpus ID: 35936687
There is no clear consensus regarding the frequency (and hence, the risk), of dyskinesias or motor fluctuations during chronic…
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Highly Cited
2000
Highly Cited
2000
Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.
R. Holloway
,
I. Shoulson
,
+66 authors
A. Watts
JAMA
2000
Corpus ID: 44312022
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies…
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Highly Cited
1996
Highly Cited
1996
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
H. Lachman
,
D. Papolos
,
T. Saito
,
Y. M. Yu
,
C. Szumlanski
,
R. Weinshilboum
Pharmacogenetics
1996
Corpus ID: 34685973
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism…
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Review
1988
Review
1988
'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa.
A. Gotham
,
R. Brown
,
C. Marsden
Brain : a journal of neurology
1988
Corpus ID: 39922641
A wide range of cognitive impairments can be observed in patients with Parkinson's disease. A close parallel exists between these…
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Highly Cited
1983
Highly Cited
1983
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
R. Burns
,
C. Chiueh
,
S. Markey
,
M. Ebert
,
D. Jacobowitz
,
I. Kopin
Proceedings of the National Academy of Sciences…
1983
Corpus ID: 12715994
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in…
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Highly Cited
1971
Highly Cited
1971
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
U. Ungerstedt
Acta physiologica Scandinavica. Supplementum
1971
Corpus ID: 9882539
A process for the treatment of sewage wherein the sludge is innoculated with a bacteria, L. plantarum, and a carbohydrate such as…
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Highly Cited
1969
Highly Cited
1969
Treatment of parkinsonism with levodopa.
M. Yahr
,
R. Duvoisin
,
M. Schear
,
R. Barrett
,
M. Hoehn
Archives of neurology
1969
Corpus ID: 30745771
Some turn this sickness yet might take, Even yet. But he: "What drug can make A wither'd palsy cease to shake?" "The Two Voices…
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Highly Cited
1964
Highly Cited
1964
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
T. Nagatsu
,
M. Levitt
,
S. Udenfriend
The Journal of biological chemistry
1964
Corpus ID: 6680748
After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of…
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