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Levodopa

Known as: beta-(3,4-Dihydroxyphenyl)-L-alanine, 3,4-Dihydroxy-L-phenylalanine, .beta.-(3,4-Dihydroxyphenyl)-L-alanine 
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (19)

2,4,5-trihydroxyphenylalanine quinone2,4-dihydroxyphenylalanine3,4,6-trihydroxyphenylalanine quinone3-O-methyl-6-fluoro-dopa

Broader (2)

Antiparkinson AgentsDopa
Carbidopa 10 MG / Levodopa 100 MG Disintegrating Oral TabletCarbidopa 10 MG / Levodopa 100 MG Oral TabletCarbidopa 10 MG / Levodopa 100 MG Oral Tablet [Sinemet]Carbidopa 25 MG / Levodopa 100 MG Disintegrating Oral Tablet

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET study
Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot… 
Highly Cited
2002
Highly Cited
2002
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a… 
Highly Cited
2001
Highly Cited
2001
Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literature
There is no clear consensus regarding the frequency (and hence, the risk), of dyskinesias or motor fluctuations during chronic… 
Highly Cited
2000
Highly Cited
2000
Pramipexole vs levodopa as initial treatment for Parkinson disease: A randomized controlled trial. Parkinson Study Group.
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies… 
Highly Cited
1996
Highly Cited
1996
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… 
Review
1988
Review
1988
'Frontal' cognitive function in patients with Parkinson's disease 'on' and 'off' levodopa.
A wide range of cognitive impairments can be observed in patients with Parkinson's disease. A close parallel exists between these… 
Highly Cited
1983
Highly Cited
1983
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in… 
Highly Cited
1971
Highly Cited
1971
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
  • U. Ungerstedt
  • Acta physiologica Scandinavica. Supplementum
  • 1971
  • Corpus ID: 9882539
A process for the treatment of sewage wherein the sludge is innoculated with a bacteria, L. plantarum, and a carbohydrate such as… 
Highly Cited
1969
Highly Cited
1969
Treatment of parkinsonism with levodopa.
Some turn this sickness yet might take, Even yet. But he: "What drug can make A wither'd palsy cease to shake?" "The Two Voices… 
Highly Cited
1964
Highly Cited
1964
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of… 
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