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Levodopa

Known as: beta-(3,4-Dihydroxyphenyl)-L-alanine, 3,4-Dihydroxy-L-phenylalanine, .beta.-(3,4-Dihydroxyphenyl)-L-alanine 
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (18)

2,4,5-trihydroxyphenylalanine quinone2,4-dihydroxyphenylalanine3,4,6-trihydroxyphenylalanine quinone3-O-methyl-6-fluoro-dopa

Broader (2)

Antiparkinson AgentsDopa
Carbidopa / LevodopaCarbidopa 10 MG / Levodopa 100 MG Disintegrating Oral TabletCarbidopa 10 MG / Levodopa 100 MG Oral TabletCarbidopa 10 MG / Levodopa 100 MG Oral Tablet [Sinemet]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome
We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y ≥ 3) with severe… 
Highly Cited
1997
Highly Cited
1997
Step initiation in Parkinson's disease: Influence of levodopa and external sensory triggers
We studied anticipatory postural adjustments contributing to gait initiation deficits in patients with Parkinson's disease (PD… 
Highly Cited
1995
Highly Cited
1995
Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease
Abstract Objective: To compare effectiveness of levodopa and levodopa combined with selegiline in treating early, mild Parkinson… 
Highly Cited
1991
Highly Cited
1991
Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs
Highly Cited
1988
Highly Cited
1988
Behavioral and neurochemical effects of acute and daily cocaine administration in rats.
Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine… 
Highly Cited
1979
Highly Cited
1979
Dementia in Parkinson disease
In 520 patients with parkinsonism seen over eight years, 168 (32%) had moderate to marked dementia. Although the demented… 
Highly Cited
1974
Highly Cited
1974
Origin and distribution of glutamate decarboxylase in substantia nigra of the cat.
Highly Cited
1966
Highly Cited
1966
Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.
Rats were depleted of tissue monoamines by reserpine treatment and were then treated with a monoamine-oxidase inhibitor… 
Highly Cited
1965
Highly Cited
1965
Inhibitors of purified beef adrenal tyrosine hydroxylase.
Highly Cited
1948
Highly Cited
1948
The chemistry of melanin; mechanism of the oxidation of dihydroxyphenylalanine by tyrosinase.
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