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Levodopa

Known as: beta-(3,4-Dihydroxyphenyl)-L-alanine, 3,4-Dihydroxy-L-phenylalanine, .beta.-(3,4-Dihydroxyphenyl)-L-alanine 
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and… 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot… 
Highly Cited
2002
Highly Cited
2002
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a… 
Highly Cited
2001
Highly Cited
2001
There is no clear consensus regarding the frequency (and hence, the risk), of dyskinesias or motor fluctuations during chronic… 
Highly Cited
2000
Highly Cited
2000
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies… 
Highly Cited
1996
Highly Cited
1996
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… 
Review
1988
Review
1988
A wide range of cognitive impairments can be observed in patients with Parkinson's disease. A close parallel exists between these… 
Highly Cited
1983
Highly Cited
1983
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in… 
Highly Cited
1971
Highly Cited
1971
  • U. Ungerstedt
  • Acta physiologica Scandinavica. Supplementum
  • 1971
  • Corpus ID: 9882539
A process for the treatment of sewage wherein the sludge is innoculated with a bacteria, L. plantarum, and a carbohydrate such as… 
Highly Cited
1969
Highly Cited
1969
Some turn this sickness yet might take, Even yet. But he: "What drug can make A wither'd palsy cease to shake?" "The Two Voices… 
Highly Cited
1964
Highly Cited
1964
After demonstration of the decarboxylation of 3,4-dihydroxyphenylalanine (dopa)’ to dopamine (I), the pathway for biosynthesis of…