Levodopa

Known as: beta-(3,4-Dihydroxyphenyl)-L-alanine, 3,4-Dihydroxy-L-phenylalanine, .beta.-(3,4-Dihydroxyphenyl)-L-alanine 
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1938-2017
050019382016

Papers overview

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Review
2017
Review
2017
Parkinson disease is the second-most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age… (More)
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Review
2015
Review
2015
Spinocerebellar ataxia (SCA) presents heterogeneous clinical phenotypes, and parkinsonism is reported in diverse SCA subtypes… (More)
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Highly Cited
2006
Highly Cited
2006
Theories of instrumental learning are centred on understanding how success and failure are used to improve future decisions… (More)
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Highly Cited
2003
Highly Cited
2003
Preclinical studies suggest ropinirole (a D2/D3 dopamine agonist) may be neuroprotective in Parkinson's disease (PD), and a pilot… (More)
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Highly Cited
2002
Highly Cited
2002
  • JAMA
  • 2002
CONTEXT Pramipexole and levodopa are effective medications to treat motor symptoms of early Parkinson disease (PD). In vitro and… (More)
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Highly Cited
2001
Highly Cited
2001
Event-related functional MRI (fMRI) was used to study blood oxygen level dependent cortical signal changes associated with… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a… (More)
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Highly Cited
2000
Highly Cited
2000
CONTEXT Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies… (More)
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Highly Cited
1996
Highly Cited
1996
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… (More)
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Highly Cited
1979
Highly Cited
1979
Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed… (More)
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