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Aromatic amino acids and modification of parkinsonism.
The interrelations between melanogenesis and extrapyramidal disease might be of fundamental importance and it was noted that chronic Parkinson's disease has a common precursor in the synthesis of both melanin and catecholamines. Expand
Brain peroxidase and catalase in Parkinson disease.
Peroxidase and catalase activities were determined in various regions of parkinsonian brains and control brains from patients with nonneurological diseases, and these enzyme changes may be causally related to the degeneration and depigmentation of the substantia nigra neurons in Parkinson disease. Expand
Effects of chronic fluoxetine administration on serotonin metabolism.
L-DOPA suppression of thyrotropin-releasing hormone response in man.
Chronic L-DOPA administration results in the inhibition of TSH secretion in response to TRH stimulation; the mechanism is unknown. Expand
Inhibition of the growth of mouse melanoma by chlorpromazine.
There was no significant effect of CPZ on the succinic oxidase and reduced nicotinamide adenine dinucleotide oxidase of either the melanoma or liver of these animals, suggesting the marked affinity of phenothiazines for melanin might be used to develop more effective melanoma chemotherapeutic agents. Expand
Effect of apomorphine on growth hormone release in humans.
Apomorphine induced marked GH elevation in all 8 healthy subjects studied but in only 1 out of four Parkinsonians, suggesting the drug may have a role in Parkinson's disease. Expand
Start hesitation--a side effect of long-term levodopa therapy.
Reports of short-term clinical trials emphasize the frequency of gastrointestinal and cardiovasal side effects of levodopa therapy in patients with Parkinson's disease. Expand
Urea-induced myoclonus: medullary glycine antagonism as mechanism of action.
In the present investigations, intraperitoneal injections of 2 g/kg urea every 15 minutes for 4 injections produced myoclonus in rats accompanied by brain urea concentrations of 6.8 X 10(-2)M, which is sevenfold higher than normal. Expand
Pupillary effects of levodopa therapy. Development of anisocoria in latent Horner's syndrome.
In a patient with Parkinson's disease and subclinical postganglionic Horner's syndrome anisocoria developed during chronic oral L-dopa therapy, this provided an opportunity to investigate the mechanism behind the development of this condition. Expand