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Leukotrienes

Known as: Leukotriene, Leukotrienes [Chemical/Ingredient] 
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate… 
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (13)

12-HPETE14,15-dihydroperoxyeicosatetraenoic acid5,15-dihydroperoxyeicosatetraenoic acid8,15-diHPETE

Broader (2)

Arachidonic AcidEicosanoids
Immediate hypersensitivityIn BloodInflammationLeukotriene Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Mechanisms of disease: Leukotrienes
From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System… 
Review
2001
Review
2001
Prostaglandins and leukotrienes: advances in eicosanoid biology.
  • C. Funk
  • Science
  • 2001
  • Corpus ID: 12564549
Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… 
Review
1999
Review
1999
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
I. Introduction II. Molecular Aspects A. PPAR isotypes: identity, genomic organization and chromosomal localization B. DNA… 
Highly Cited
1999
Highly Cited
1999
Characterization of the human cysteinyl leukotriene CysLT1 receptor
The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… 
Highly Cited
1996
Highly Cited
1996
The PPARα–leukotriene B4 pathway to inflammation control
Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent… 
Review
1994
Review
1994
The Role of Leukotrienes in Inflammation
  • W. Henderson
  • Annals of Internal Medicine
  • 1994
  • Corpus ID: 34810055
Leukotrienes, together with prostaglandins, thromboxanes, and lipoxins, are the major constituents of a group of biologically… 
Review
1990
Review
1990
Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.
THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was… 
Highly Cited
1990
Highly Cited
1990
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
LEUKOTRIENES, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory… 
Review
1987
Review
1987
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects.
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… 
Highly Cited
1980
Highly Cited
1980
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to… 
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