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From the Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System… Expand Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that… Expand I. Introduction II. Molecular Aspects A. PPAR isotypes: identity, genomic organization and chromosomal localization B. DNA… Expand The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… Expand Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent… Expand THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity 1 , 2 three to four decades before it was… Expand Arachidonic acid is released from membrane phospholipids upon cell stimulation (for example, by immune complexes and calcium… Expand Leukotrienes B4, C4, and D4, members of a recently discovered family of substances biosynthesized from arachidonic acid, were… Expand Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to… Expand Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig… Expand