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Leukotrienes

Known as: Leukotriene, Leukotrienes [Chemical/Ingredient] 
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate… 
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (13)

12-HPETE14,15-dihydroperoxyeicosatetraenoic acid5,15-dihydroperoxyeicosatetraenoic acid8,15-diHPETE

Broader (2)

Arachidonic AcidEicosanoids
Immediate hypersensitivityIn BloodInflammationLeukotriene Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface
G protein-coupled receptors (GPCRs) are ubiquitous and essential in modulating virtually all physiological processes. These… 
Review
1992
Review
1992
Designing therapeutically effective 5-lipoxygenase inhibitors.
Highly Cited
1989
Highly Cited
1989
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites.
Highly Cited
1987
Highly Cited
1987
Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin.
Because infiltration of mononuclear cells and fibroblast proliferation are associated in chronic inflammatory lesions, we tested… 
Highly Cited
1986
Highly Cited
1986
Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids.
Highly Cited
1985
Highly Cited
1985
Leukotrienes B4, C4 and D4 stimulate DNA synthesis in cultured human epidermal keratinocytes
Leukotrienes in psoriatic skin lesions are potent mediators of inflammation. We have studied the capacity of leukotrienes to… 
Highly Cited
1983
Highly Cited
1983
Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids.
Highly Cited
1982
Highly Cited
1982
IgE-dependent release of leukotriene C4 from alveolar macrophages
Slow reacting substances (SRS) are potent bronchoconstrictors that are thought to be important in the pathophysiology of asthma1… 
Highly Cited
1981
Highly Cited
1981
Transformation of arachidonic acid in leukocytes. Isolation and structural analysis of a novel dihydroxy derivative.
Highly Cited
1981
Highly Cited
1981
Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes.
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