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Leukotrienes

Known as: Leukotriene, Leukotrienes [Chemical/Ingredient] 
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate… 
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (13)

12-HPETE14,15-dihydroperoxyeicosatetraenoic acid5,15-dihydroperoxyeicosatetraenoic acid8,15-diHPETE

Broader (2)

Arachidonic AcidEicosanoids
Immediate hypersensitivityIn BloodInflammationLeukotriene Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Biosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO… 
Highly Cited
2006
Highly Cited
2006
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor
Nucleotides and cysteinyl‐leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G… 
Highly Cited
2003
Highly Cited
2003
Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate… 
Highly Cited
1991
Highly Cited
1991
Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects.
Urinary leukotriene E4 (LTE4) concentrations have been measured in six asthmatic patients with aspirin sensitivity and in five… 
Review
1990
Review
1990
The regulation and cellular functions of phosphatidylcholine hydrolysis.
Various aspects of phospholipase A 2 and phosphoinositide-specific phospholipase C have been reviewed extensively. In the present… 
Highly Cited
1989
Highly Cited
1989
Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils.
Highly Cited
1983
Highly Cited
1983
Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4.
5-Lipoxygenase pathway-derived products of arachidonic acid released by human eosinophils activated in vitro have been measured… 
Highly Cited
1980
Highly Cited
1980
Leukotrienes are potent constrictors of human bronchi
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including immunological challenge, and has long… 
Highly Cited
1980
Highly Cited
1980
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro.
The pharmacologic activities of leukotrienes C-1 and D(LTC-1 and LTD), constituents of slow reacting substance of anaphylaxis… 
Highly Cited
1979
Highly Cited
1979
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig… 
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