FAQ

Leukotrienes

Known as: Leukotriene, Leukotrienes [Chemical/Ingredient] 
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate… (More)

Topic mentions per year

Topic mentions per year

1976-2017
020040060019762017

Related topics

Related topics

26 relations

Narrower (12)

12-HPETE5,15-dihydroperoxyeicosatetraenoic acid8,15-diHPETE8-hydroperoxyeicosatetraenoic acid
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Broader (2)

Arachidonic AcidEicosanoids
Immediate hypersensitivityIn BloodInflammationLeukotriene Receptor
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Leukotrienes
physiological aspects
agonists
Arachidonic Acid
Inflammation
Eicosanoids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review.
Eosinophilic gastrointestinal disorders, including eosinophilic esophagitis, gastroenteritis, and colitis, refer to a spectrum of… (More)
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Highly Cited
2006
Highly Cited
2006
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.
Nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G… (More)
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Highly Cited
2000
Highly Cited
2000
The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes
Adaptive immune responses begin after antigen-bearing dendritic cells (DCs) traffic from peripheral tissues to lymph nodes. Here… (More)
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Highly Cited
1999
Highly Cited
1999
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
The cysteinyl leukotrienes-leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE4)-are important mediators of human… (More)
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Highly Cited
1998
Highly Cited
1998
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue… (More)
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Highly Cited
1996
Highly Cited
1996
The PPARalpha-leukotriene B4 pathway to inflammation control.
Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent… (More)
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Highly Cited
1983
Highly Cited
1983
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.
Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins… (More)
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Highly Cited
1981
Highly Cited
1981
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
Leukotrienes B4, C4, and D4, members of a recently discovered family of substances biosynthesized from arachidonic acid, were… (More)
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Highly Cited
1980
Highly Cited
1980
Leukotrienes are potent constrictors of human bronchi.
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including immunological challenge, and has long… (More)
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Highly Cited
1980
Highly Cited
1980
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.
Arachidonic acid is metabolised either by cyclooxygenases to produce prostaglandins and thromboxanes or by lipoxygenases to… (More)
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