Skip to search formSkip to main contentSkip to account menu

LY2584702

Known as: p70S6K Inhibitor LY2584702 
An orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. p70S6K inhibitor LY2584702 inhibits ribosomal protein S6… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

LY2584702 tosylate
NCIt Antineoplastic Agent Terminology

Broader (2)

PyrazolesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Downregulation of long noncoding RNA Sox2ot protects PC‐12 cells from hydrogen peroxide–induced injury in spinal cord injury via regulating the miR‐211‐myeloid cell leukemia‐1 isoform2 axis
This study aimed to investigate the effects and possible mechanisms of long noncoding RNA (lncRNA) Sox2 overlapping transcript… 
2013
2013
Targeting mTOR to Overcome Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer Cells
Aims Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown dramatic clinical benefits in advanced… 
Highly Cited
2009
Highly Cited
2009
Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.
Human papilloma virus (HPV) infection of the uterine cervix is linked to the pathogenesis of cervical cancer. Preclinical in… 
2007
2007
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
Stimulation of cardiac beta-adrenergic receptors (beta-AR) activates both the G(s)- and G(i)-coupled signaling cascades… 
2007
2007
Rosiglitazone, an Agonist of PPARγ, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2
PPARγ ligands inhibit the proliferation of non-small cell lung carcinoma (NSCLC) cells in vitro. The mechanisms responsible for… 
2006
2006
Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells
Arsenic trioxide (As2O3) exhibits important antitumor activities in vitro and in vivo, but the precise mechanisms by which it… 
Highly Cited
2004
Highly Cited
2004
Aerosol Delivery of Glucosylated Polyethylenimine/Phosphatase and Tensin Homologue Deleted on Chromosome 10 Complex Suppresses Akt Downstream Pathways in the Lung of K-ras Null Mice
Difficulties in achieving long-term survival of lung cancer patients treated with conventional therapies suggest that novel… 
2002
2002
Model of inhibition of the NPM-ALK kinase activity by herbimycin A.
Anaplastic large cell lymphoma (ALCL) exhibiting the t(2;5) translocation is characterized by the resulting expression of the… 
Review
1996
Review
1996
The role of eIF4 in cell proliferation.
Translational control has a key role in regulating cell growth. The mRNA binding translation factors (eIF4s) selectively modulate… 
Highly Cited
1995
Highly Cited
1995
Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma.
Lactogens [prolactin (Prl) and growth hormone] stimulate phosphorylation of the 40S ribosomal protein, S6, in Nb2 cells by… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)