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LY2584702

Known as: p70S6K Inhibitor LY2584702 
An orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. p70S6K inhibitor LY2584702 inhibits ribosomal protein S6… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

LY2584702 tosylate
NCIt Antineoplastic Agent Terminology

Broader (2)

PyrazolesPyrimidines

Papers overview

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Highly Cited
2010
Highly Cited
2010
New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.
Highly Cited
2009
Highly Cited
2009
Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy
The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents… 
Highly Cited
2008
Highly Cited
2008
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.
Highly Cited
2007
Highly Cited
2007
RAD001 Inhibits Human Ovarian Cancer Cell Proliferation, Enhances Cisplatin-Induced Apoptosis, and Prolongs Survival in an Ovarian Cancer Model
Purpose: mTOR (mammalian target of rapamycin) plays a central role in regulating cell growth and cell cycle progression and is… 
Highly Cited
2006
Highly Cited
2006
Early signaling responses to divergent exercise stimuli in skeletal muscle from well‐trained humans
Skeletal muscle from strength‐ and endurance‐trained individuals represents diverse adaptive states. In this regard, AMPK‐PGC‐1… 
Highly Cited
2006
Highly Cited
2006
Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
Growth factor receptors and cell signaling factors play a crucial role in human carcinomas and have been studied in ovarian… 
Highly Cited
2006
Highly Cited
2006
Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma
Purpose: Activation of mitogen-activated protein kinase (MAPK) and members of the Akt pathway have been shown to promote cell… 
Highly Cited
1999
Highly Cited
1999
p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex
ABSTRACT p70 S6 kinase (p70S6K) is an important regulator of cell proliferation. Its activation by growth factor requires… 
Highly Cited
1996
Highly Cited
1996
Rapamycin resistance tied to defective regulation of p27Kip1
The potent antiproliferative activity of the macrolide antibiotic rapamycin is known to involve binding of the drug to its… 
Highly Cited
1994
Highly Cited
1994
Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
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