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LY2584702

Known as: p70S6K Inhibitor LY2584702 
An orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. p70S6K inhibitor LY2584702 inhibits ribosomal protein S6… 
National Institutes of Health

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4 relations

Narrower (1)

LY2584702 tosylate
NCIt Antineoplastic Agent Terminology

Broader (2)

PyrazolesPyrimidines

Papers overview

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Highly Cited
2012
Highly Cited
2012
Characterization of the cellular action of the MSK inhibitor SB-747651A.
MSK1 (mitogen- and stress-activated kinase 1) and MSK2 are nuclear protein kinases that regulate transcription downstream of the… 
Highly Cited
2010
Highly Cited
2010
Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3β, and apoptosis
Post-conditioning by repetitive cycles of reperfusion/ischemia after prolonged ischemia protects the heart from infarction. The… 
Highly Cited
2010
Highly Cited
2010
AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth
The serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and… 
Highly Cited
2009
Highly Cited
2009
Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions.
Human papilloma virus (HPV) infection of the uterine cervix is linked to the pathogenesis of cervical cancer. Preclinical in… 
2006
2006
Cooperative mitogenic signaling by G protein‐coupled receptors and growth factors is dependent on Gq/11
Previously we reported that the G protein‐coupled receptor (GPCR) agonist thrombin potentiated the mitogenic effect of epidermal… 
Highly Cited
2005
Highly Cited
2005
Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of… 
Highly Cited
2004
Highly Cited
2004
Aerosol Delivery of Glucosylated Polyethylenimine/Phosphatase and Tensin Homologue Deleted on Chromosome 10 Complex Suppresses Akt Downstream Pathways in the Lung of K-ras Null Mice
Difficulties in achieving long-term survival of lung cancer patients treated with conventional therapies suggest that novel… 
Highly Cited
2003
Highly Cited
2003
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia
The Raf/MEK/ERK kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using… 
Review
1996
Review
1996
The role of eIF4 in cell proliferation.
Translational control has a key role in regulating cell growth. The mRNA binding translation factors (eIF4s) selectively modulate… 
Highly Cited
1995
Highly Cited
1995
Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma.
Lactogens [prolactin (Prl) and growth hormone] stimulate phosphorylation of the 40S ribosomal protein, S6, in Nb2 cells by… 
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