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LY 293558

Known as: LY-293558, LY293558 
National Institutes of Health

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tezampanel

Papers overview

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2013
2013
Efficacy of the GluK1/AMPA Receptor Antagonist LY293558 against Seizures and Neuropathology in a Soman-Exposure Model without Pretreatment and its Pharmacokinetics after Intramuscular Administration
Control of brain seizures after exposure to nerve agents is imperative for the prevention of brain damage and death. Animal… 
2003
2003
The selective iGluR1-4 (AMPA) antagonist LY300168 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioural signs of morphine withdrawal
2003
2003
Pharmacological heterogeneity of release-regulating presynaptic AMPA/kainate receptors in the rat brain: study with receptor antagonists
Highly Cited
2002
Highly Cited
2002
The Group II Metabotropic Glutamate Receptor Agonist (−)-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted…
Recent studies have indicated that the selective group II metabotropic glutamate (mGlu) receptor agonist (−)-2-oxa-4-aminobicyclo… 
2002
2002
AMPA receptor antagonist LY293558 reverses preproenkephalin mRNA overexpression in the striatum of 6‐OHDA‐lesioned‐rats treated with l‐dopa
Striatal neurons that contain GABA and enkephalin and project to the external segment of the pallidum are thought to be… 
2002
2002
Effect of Intrathecal Non-NMDA EAA Receptor Antagonist LY293558 in Rats: A New Class of Drugs for Spinal Anesthesia
Background Excitatory amino acid receptors are important for both sensory and motor function in the spinal cord. We studied the… 
1999
1999
AMPA antagonist LY293558 blocks the development, without blocking the expression, of behavioral sensitization to morphine
Morphine (3.0 mg/kg, SC) stimulates locomotor activity in rats, and this effect sensitizes with repeated intermittent treatment… 
1999
1999
Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.
1999
1999
Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia.
1999
1999
Measurement of calcium flux through ionotropic glutamate receptors using Cytostar-T scintillating microplates
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