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LRP8 gene

Known as: APOLIPOPROTEIN E RECEPTOR 2, APOER2, Low Density Lipoprotein Receptor-Related Protein 8, Apolipoprotein E Receptor Gene 
This gene plays a role in ligand binding and signaling.
National Institutes of Health

Related topics

Related topics

10 relations
EndocytosisIntercellular Communication ProcessLRP8 protein, humanLigand Binding

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LRP8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation.
Reelin is a large extracellular matrix protein with relevant roles in mammalian central nervous system including neurogenesis… 
Highly Cited
2015
Highly Cited
2015
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation
Review
2014
Review
2014
Trafficking regulation of proteins in Alzheimer’s disease
The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer’s disease (AD). Aβ is… 
Highly Cited
2011
Highly Cited
2011
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
Coordinated migration of neurons in the developing and adult brain is essential for its proper function. The secreted… 
Highly Cited
2009
Highly Cited
2009
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
Binding of activated protein C (APC) to cells triggers multiple beneficial cytoprotective activities that suppress apoptosis… 
Highly Cited
2009
Highly Cited
2009
Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model
Highly Cited
2009
Highly Cited
2009
Identification of Coagulation Factor XI as a Ligand for Platelet Apolipoprotein E Receptor 2 (ApoER2)
Objective—Factor XI (FXI) promotes hemostasis and thrombosis through enhancement of thrombin generation and has been shown to… 
Review
2007
Review
2007
Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
Highly Cited
2007
Highly Cited
2007
An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.
Our previous genomewide linkage scan of 428 nuclear families (GeneQuest) identified a significant genetic susceptibility locus… 
Highly Cited
2005
Highly Cited
2005
F-Spondin Interaction with the Apolipoprotein E Receptor ApoEr2 Affects Processing of Amyloid Precursor Protein
ABSTRACT A recent study showed that F-spondin, a protein associated with the extracellular matrix, interacted with amyloid… 
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