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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
The A β-dependent and Aβ-independent mechanisms that link Apo-E4 status with AD risk are discussed, and how to design effective strategies for AD therapy by targeting ApO-E is considered.
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)*
It is demonstrated that apoE-TREM2 interaction in microglia plays critical roles in modulating phagocytosis of apo E-bound apoptotic neurons and establish a critical link between two proteins whose genes are strongly linked to the risk for AD.
APP processing in Alzheimer's disease
Current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites are reviewed.
Chaperones increase association of tau protein with microtubules
The results suggest that up-regulation of molecular chaperones may suppress formation of neurofibrillary tangles by partitioning tau into a productive folding pathway and thereby preventing tau aggregation.
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
Does insulin dysfunction play a role in Alzheimer's disease?
Intraneuronal Aβ42 Accumulation in Human Brain
Proteolytic processing of Alzheimer’s β‐amyloid precursor protein
- Han Zhang, Qilin Ma, Yun-wu Zhang, Huaxi Xu
- Chemistry, BiologyJournal of neurochemistry
- 1 January 2012
J. Neurochem. (2012) 120 (Suppl. 1), 9–21.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome
The identification of the role of SNX27 in synaptic function establishes a new molecular mechanism of Down's syndrome pathogenesis and rescues synaptic and cognitive deficits.