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LPC-011

 
National Institutes of Health

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3 relations

Broader (2)

Hydroxamic AcidsThreonine
analogs & derivatives

Papers overview

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2018
2018
Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells
Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a… Expand
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2017
2017
Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
BackgroundChlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related… Expand
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2016
2016
High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.
OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses… Expand
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