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National Institutes of Health
analogs & derivatives
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Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells
Front. Cell. Infect. Microbiol.
Corpus ID: 46951422
Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a…
Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
Erik D. Cram
Corpus ID: 8153710
BackgroundChlamydia species are obligate intracellular bacteria that infect a broad range of mammalian hosts. Members of related…
High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.
The Journal of antimicrobial chemotherapy
Corpus ID: 15791870
OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses…
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