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LMP2A-Specific Cytotoxic T-Lymphocytes

Known as: LMP2A-CTL, EBV-Specific Cytotoxic T-Lymphocytes, LMP2A CTL 
A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP2A), with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
024619802018

Related topics

Related topics

2 relations
Autologous Epstein-Barr Virus-Specific Cytotoxic T Lymphocytesautologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell)

Related mentions per year

Related mentions per year

1974-2018
197019801990200020102020
LMP2A-Specific Cytotoxic T-Lymphocytes
autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (cell)
Autologous Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes

Papers overview

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2008
2008
Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration.
A major problem in generating effective antitumor CTL responses is that most tumors express self-antigens to which the immune… (More)
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Highly Cited
2007
Highly Cited
2007
CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue.
The inability of HIV-1-specific CTL to fully suppress virus replication as well as the failure of administration of exogenous CTL… (More)
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2007
2007
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
PURPOSE To investigate the potential of the DNA hypomethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) to improve the… (More)
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2004
2004
Treatment of melanoma with 5-fluorouracil or dacarbazine in vitro sensitizes cells to antigen-specific CTL lysis through perforin/granzyme- and Fas-mediated pathways.
Several factors may influence sensitivity of melanoma cells to CTL lysis. One is the avidity of the CTL TCR. A second is that… (More)
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2002
2002
Critical components of a DNA fusion vaccine able to induce protective cytotoxic T cells against a single epitope of a tumor antigen.
DNA vaccines can activate immunity against tumor Ags expressed as MHC class I-associated peptides. However, priming of CD8(+) CTL… (More)
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2001
2001
The generation of LMP2a-specific cytotoxic T lymphocytes for the treatment of patients with Epstein-Barr virus-positive Hodgkin disease.
Based upon the success of using polyclonal, Epstein-Barr virus (EBV)-specific CTL lines for the prophylaxis and treatment of… (More)
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2001
2001
A canarypox vector-expressing cytomegalovirus (CMV) phosphoprotein 65 induces long-lasting cytotoxic T cell responses in human CMV-seronegative subjects.
The major matrix phosphoprotein 65 (pp65) of cytomegalovirus (CMV) is an important target of HLA-restricted cytotoxic T cells… (More)
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Highly Cited
2000
Highly Cited
2000
Relevance of the tumor antigen in the validation of three vaccination strategies for melanoma.
Many preclinical studies of cancer immunotherapy are based on the testing of a single vaccination strategy in several tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected…
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) and latent membrane proteins (LMP) are the only antigens consistently… (More)
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1998
1998
Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity.
We have evaluated the potential of conferring protective immunity to herpes simplex virus type 2 (HSV-2) by selectively inducing… (More)
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