R. Hoffman

Publications200
h-index41
Citations5,981
Highly Influential Citations107
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Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells1
Endogenous ligands from damaged cells, so-called damage-associated molecular pattern molecules, can activate innate immunity via TLR4 signaling. Hepatic warm ischemia and reperfusion (I/R) injury and… Expand
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Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
Nitric oxide (NO) is a short-lived biologic mediator that is shown to be induced in various cell types and to cause many metabolic changes in target cells. Inhibition of tumor cell growth and… Expand
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Reactive nitrogen intermediates suppress the primary immunologic response to Listeria.
Reactive nitrogen intermediates (RNI), e.g., nitric oxide derived from a terminal guanido nitrogen atom of L-arginine, exhibit potent antimicrobial activity in vitro. The function of these… Expand
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Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa.
It has been demonstrated previously that the inducible isoform of nitric oxide synthase (iNOS) is present throughout the intestinal tract in various inflammatory disease processes. Here we… Expand
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A Role for Connexin43 in Macrophage Phagocytosis and Host Survival after Bacterial Peritoneal Infection1
The pathways that lead to the internalization of pathogens via phagocytosis remain incompletely understood. We now demonstrate a previously unrecognized role for the gap junction protein connexin43… Expand
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Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.
Activated macrophages have been demonstrated to metabolize the amino acid L-arginine by the oxidative pathway to produce nitric oxide, citrulline, and NO2-/NO3-. Nitric oxide has been shown to be… Expand
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N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats.
OBJECTIVE To test the hypothesis that nitric oxide (NO) is involved in the pathophysiology of arthritis. METHODS Arthritis was induced in male Lewis rats by the injection of adjuvant into the base… Expand
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Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.
Nitric oxide (NO) is an important effector molecule that is involved in immune regulation and host defense. In this study, highly purified NLDC 145+ (DEC-205+) MHC class II(bright) B7-2+ dendritic… Expand
  • 239
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Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.
The present study was designed to determine whether .N = O produced in vivo during the rejection of histoincompatible tissues might permit serum NO2-/NO3- levels to serve as markers of a rejection… Expand
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Leukocyte-Derived Inducible Nitric Oxide Synthase Mediates Murine Postoperative Ileus
Objective:To provide evidence that iNOS expression solely in leukocytes plays a role in postoperative ileus. Summary Background Data:Intestinal handling initiates a molecular and cellular muscularis… Expand
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