Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
The results show that flow FISH can be used to measure specific nucleotide repeat sequences in single cells and indicate that the very large replicative potential of lymphocytes is only indirectly related to telomere length.
Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy.
Anti-CMV cellular therapy was successful in 5 of 7 patients, whereas in 2 of7 patients, who received an intensified immune suppression at the time of or after T-cell therapy, only transient reductions in virus load were obtained.
Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells
- Jean‐Marie Ramirez, N. Brembilla, C. Chizzolini
- Biology, ChemistryEuropean Journal of Immunology
- 1 September 2010
The data provide compelling evidence that AHR activation participates in shaping human CD4+ T‐cell polarization favoring the emergence of a distinct subset of IL‐22‐producing cells that are independent from the Th17 lineage.
Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
In conclusion, stem cell transplantation is associated with a severe immune deficiency and B- and T-cell counts normalize during the first months after transplantation, but in particular, T- cell immunity may remain impaired for years.
Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity.
It is concluded that during the first year after transplantation, the absence of an immune response is due mainly to the loss of an adequate T-cell repertoire.
Human NK cells can control CMV infection in the absence of T cells.
- T. Kuijpers, P. Baars, C. Dantin, M. van den Burg, R. W. V. van Lier, E. Roosnek
- Medicine, BiologyBlood
- 1 August 2008
To the editor: A 3-month-old girl, the first child of consanguineous parents with a family history of unexplained febrile episodes including a death from infection of the eldest brother of the…
APRIL secreted by neutrophils binds to heparan sulfate proteoglycans to create plasma cell niches in human mucosa.
It is found that mucosal humoral immunity in APRIL-deficient mice is less persistent than in WT mice, and production of APRIL by inflammation-recruited neutrophils may create plasma cell niches in MALT to sustain a local antibody production.
Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants.
The thymus is essential for the restoration of the T-cell repertoire after bone marrow transplantation (BMT) and this might explain why, in recipients of a T- cell-depleted graft, immune recovery is delayed.
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
The data point to the presence of T cells with intermediate effector-like functions and suggest that these subsets consist of T lymphocytes that are evolving toward a more differentiated effector or effectors-memory stage.