LEPR gene

Known as: OBR, Leptin Receptor Gene, LEPR 
This gene plays a role in transcriptional regulation via activation of the STAT signal transduction pathway. The gene is also involved in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
010203019962018

Papers overview

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Highly Cited
2001
Highly Cited
2001
Type 2 diabetes is caused by a combination of beta-cell dysfunction and insulin resistance. Over time, hyperglycemia worsens, a… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND AND AIM The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body… (More)
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Highly Cited
2000
Highly Cited
2000
Embryonic implantation is a crucial event for the human reproductive function. Cytokines and paracrine molecules have been… (More)
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Highly Cited
1998
Highly Cited
1998
Leptin acts on specific brain regions to affect body weight regulation. As leptin is made by white adipose tissue, it is thought… (More)
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Highly Cited
1997
Highly Cited
1997
Leptin is a 167-aa protein that is secreted from adipose tissue and is important in the regulation of energy balance. It also… (More)
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Highly Cited
1997
Highly Cited
1997
The obese (ob) gene product, leptin, a peptide hormone, which is synthesized in adipocytes, is a satiety factor and is involved… (More)
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Highly Cited
1997
Highly Cited
1997
Leptin is a hormone produced in adipose cells that regulates energy expenditure, food intake, and adiposity. In mice, we observed… (More)
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Highly Cited
1996
Highly Cited
1996
OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an… (More)
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Highly Cited
1996
Highly Cited
1996
The rat fatty (fa) mutation produces profound obesity of early onset caused by hyperphagia, defective nonshivering thermogenesis… (More)
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Highly Cited
1996
Highly Cited
1996
Leptin-receptor gene expression in hypothalamic tissue from lean and obese humans was examined. The full-length leptin receptor… (More)
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