LEP gene

Known as: OBESE, MOUSE, HOMOLOG OF, OB, Leptin (Murine Obesity Homolog) Gene 
This gene plays a role in the modulation of appetite and the regulation of body fat storage.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
010020030019802018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND & AIMS : Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, was recently identified in the rat… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 1
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The adipocyte-specific hormone leptin, the product of the obese (ob) gene,regulates adipose-tissue mass through hypothalamic… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 2
  • table 1
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Leptin affects food intake and body weight by actions on the hypothalamus. Although leptin resistance is common in obesity… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 1
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Leptin administration reduces obesity in leptin-deficient ob/ob mice; its effects in obese humans, who have high circulating… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The leptin receptor (OB-R) is a single membrane-spanning protein that mediates the weight regulatory effects of leptin (OB… (More)
Is this relevant?