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LATS1 gene

Known as: WARTS, LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Gene, LATS1 
This gene is involved in the maintenance of genomic stability.
National Institutes of Health

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Related topics

6 relations
Cell Cycle ControlLATS1 protein, humanPhosphorylationSerine/Threonine Phosphorylation

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LATS1 wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
Localization of Hippo signalling complexes and Warts activation in vivo
Hippo signalling controls organ growth and cell fate by regulating the activity of the kinase Warts. Multiple Hippo pathway… 
Highly Cited
2014
Highly Cited
2014
The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.
Highly Cited
2007
Highly Cited
2007
RASSF1A Is Part of a Complex Similar to the Drosophila Hippo/Salvador/Lats Tumor-Suppressor Network
Highly Cited
2007
Highly Cited
2007
Fat and Expanded act in parallel to regulate growth through Warts
The conserved Drosophila tumor suppressors Fat and Expanded have both recently been implicated in regulating the activity of the… 
Highly Cited
2006
Highly Cited
2006
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
Highly Cited
2005
Highly Cited
2005
Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers
Purpose: LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the… 
Highly Cited
2005
Highly Cited
2005
Human LATS1 is a mitotic exit network kinase.
The kinase LATS/WARTS is a tumor suppressor protein conserved in evolution, but its function at the molecular level is not well… 
Highly Cited
2002
Highly Cited
2002
Molecular Alterations of h-warts/LATS1 Tumor Suppressor in Human Soft Tissue Sarcoma
h-warts/LATS1 is a human homolog of the Drosophila warts tumor suppressor gene, which functions as a component of the mitotic… 
Highly Cited
2001
Highly Cited
2001
Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
The lats gene encodes a family of proteins conserved from insects to humans. Drosophila carrying lats mutant cells or mice… 
1972
1972
Familial Acute Myeloid Leukaemia with Acquired Pelger-Huët Anomaly and Aneuploidy of C Group
All five members of one generation in an Icelandic family were affected by acute myeloid leukaemia or preleukaemia. Two sibs died… 
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