Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma

@article{Jiang2006PromoterHD,
  title={Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma},
  author={Zheng Jiang and Xingang Li and Jin Hu and Wei Zhou and Da-ru Lu},
  journal={Neuroscience Research},
  year={2006},
  volume={56},
  pages={450-458}
}

Molecular Alterations and Expression Dynamics of LATS1 and LATS2 Genes in Non-Small-Cell Lung Carcinoma

TLDR
LATS1 is an independent prognostic factor and may play an important role inNSCLC progression and may serve as a novel therapeutic target of NSCLC.

Decreased expression of LATS1 is correlated with the progression and prognosis of glioma

TLDR
It is found that mRNA and protein of LATS1 expression is significantly downregulated in glioma compared with normal control brain tissues and its downregulated expression may contribute toglioma progression.

LATS2 is De-methylated and Overexpressed in Nasopharyngeal Carcinoma and Predicts Poor Prognosis

TLDR
Functional studies showed that the suppression of LATS2 expression in nasopharyngeal carcinoma (5-8F and CNE2) cell lines by using specific small interfering (siRNA) resulted in the inhibition of growth, induction of apoptosis and S-phase cell cycle increase.

Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas

TLDR
The results suggest that an abnormal Hippo signaling pathway is involved in the pathogenesis of most sporadic schwannomas.

Methylation‑associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma.

TLDR
For the first time, the inactivation of LATS1 by promoter methy-lation is demonstrated and it is a tumor suppressor in kidney cancer.

Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer

TLDR
The results indicate that LATS1 may play an important role in NSCLC, and may serve as a novel therapeutic target of NSCLE, and could regulate the nuclear location of YAP.

Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation.

TLDR
Investigating large tumor suppressor 1 (LATS1) expression, promoter hypermethylation, and microsatellite instability in colorectal cancer (CRC) found reduced expression may promote progression of CRC.

Hypermethylation of promoter region of LATS1--a CDK interacting protein in oral squamous cell carcinomas--a pilot study in India.

TLDR
This is the first study to have explored and identified positive association between LATS1 promoter hypermethylation with histopathological features in oral squamous cell carcinomas.

Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73.

TLDR
The results suggest that Kpm/Lats2 is involved in the fate of p73 through the phosphorylation of YAP2 by Kpm or Lats2 and the induction of p 73 target genes that underlie chemosensitivity of leukemic cells.
...

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TLDR
Hypermethylation of the promoter regions of LATS1 and LATS2 likely plays an important role in the down-regulation of their mRNA levels in breast cancers, and breast cancers with a decreased expression of Lats2 mRNA levels have a biologically aggressive phenotype.

Lats2, a putative tumor suppressor, inhibits G1/S transition

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A model in which a combination of mammalian Lats2 and Lats1 control cell proliferation by negatively regulating different cell cycle check points is proposed.

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