LATS1 protein, human

Known as: LATS Homolog 1, LATS, large tumor suppressor, homolog 1 (Drosophila) protein, human, LATS1 Protein 
Serine/threonine-protein kinase LATS1 (1130 aa, ~127 kDa) is encoded by the human LATS1 gene. This protein plays a role in both mitosis and serine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Large tumor suppressor (LATS)1/2 protein kinases transmit Hippo signaling in response to intercellular contacts and serum levels… (More)
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Highly Cited
2008
Highly Cited
2008
LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS subfamily of AGC (protein kinase A/PKG… (More)
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Highly Cited
2006
Highly Cited
2006
Downregulation of the LATS1 tumour suppressor protein kinase contributes to tumour formation in mammals and flies. Strikingly… (More)
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Highly Cited
2006
Highly Cited
2006
LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but their methylation statuses are still… (More)
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Highly Cited
2005
Highly Cited
2005
Originally identified in Drosophila melanogaster, the Warts(Wts)/Lats protein kinase has been proposed to function with two other… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the promoter… (More)
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Highly Cited
2004
Highly Cited
2004
LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show… (More)
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Highly Cited
2002
Highly Cited
2002
The LATS1 gene is a mammalian member of the novel lats tumor suppressor family. Both lats mosaic flies and LATS1 deficient mice… (More)
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Highly Cited
1999
Highly Cited
1999
The lats gene has been identified as a tumour suppressor in Drosophila melanogaster using mosaic screens. Mosaic flies carrying… (More)
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Highly Cited
1999
Highly Cited
1999
We have previously used mosaic flies to screen for tumour suppressors or negative regulators of cell proliferation. The cellular… (More)
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