Skip to search formSkip to main contentSkip to account menu

L 732138

Known as: L-732,138 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines
SummarySubstance P and neurokinin-1 (NK-1) receptor antagonists respectively induce cell proliferation and cell inhibition in… 
Highly Cited
2008
Highly Cited
2008
NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2
SummaryIt has been demonstrated that substance P (SP) induces cell proliferation and neurokinin-1 (NK-1) receptor antagonists… 
2008
2008
Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands
The mucosa of the proximal airways defends itself and the lower airways from inhaled irritants such as capsaicinoids, allergens… 
2008
2008
Substance P depolarizes striatal projection neurons and facilitates their glutamatergic inputs
The striatum is the main basal ganglia input nucleus, receiving extensive glutamatergic inputs from cortex and thalamus. Medium… 
2006
2006
The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones.
2005
2005
Postsynaptic actions of substance P on rat periaqueductal grey neurons in vitro
Highly Cited
2002
Highly Cited
2002
Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist
Highly Cited
2000
Highly Cited
2000
Capsaicin induces a slow inward current which is not mediated by substance P in substantia gelatinosa neurons of the rat spinal cord
Highly Cited
1995
Highly Cited
1995
Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage.
The 3,5-bis(trifluoromethyl)benzyl ester of N-acetyl-L-tryptophan 1 (L-732,138) has been identified previously as a potent and… 
Highly Cited
1994
Highly Cited
1994
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)