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Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study.
  • T. Satoh, R. Xu, +16 authors Y. Bang
  • Medicine
  • Journal of clinical oncology : official journal…
  • 1 July 2014
TLDR
Lapatinib plus paclitaxel demonstrated activity in the second-line treatment of patients with HER2 FISH-positive IHC3+ advanced gastric cancer but did not significantly improve OS in the intent-to-treat population. Expand
Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naïve patients with advanced gastric cancer.
TLDR
SOX is as effective as CS for AGC with favorable safety profile, therefore SOX can replace CS. Expand
Asian Consensus Report on Functional Dyspepsia
TLDR
This consensus developed by Asian experts shows distinctive features of functional dyspepsia in Asia and will provide a guide to the diagnosis and management of functional Dyspepsio for Asian primary care physicians. Expand
Gastroduodenitis associated with ulcerative colitis
TLDR
The high prevalence of GDUC suggests that the gut inflammatory reaction in UC may not be restricted to the large intestine and Administered steroids might conceal GDUC, and more aggressive UC such as active pancolitis may be related to the development ofGDUC. Expand
Evidence-based clinical practice guidelines for functional dyspepsia
TLDR
The proposed pharmacological treatment is divided into two steps: initial treatment including an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); second-line treatment including anxiolytics, antidepressants, and Japanese traditional medicine (weak recommendation). Expand
pylori and Gastric Cancer : The Asian Enigma
The actual distribution of Helicobacter pylori infection and its related diseases in various Asian countries is controversial. Only limited information is available regarding this issue. We discussExpand
Comparison of endoscopic findings with symptom assessment systems (FSSG and QUEST) for gastroesophageal reflux disease in Japanese centres
TLDR
Endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) are compared to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST), a written questionnaire developed in Japan. Expand
Oxidative stress induces gastric epithelial permeability through claudin-3.
TLDR
This is the first study to demonstrate that claudin-3 is involved in the barrier function of gastric epithelial cells and that rebamipide abolishes the H2O2-induced decrease in claudIn-3 protein. Expand
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.
TLDR
Patients with precancerous lesions (molecular alterations) that do not reverse after H. pylori treatment, represent the "point of no return" and may be at high risk for the development of GC, therefore, earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancersous lesions. Expand
Alteration of histological gastritis after cure of Helicobacter pylori infection
Background : It is still disputed whether gastric atrophy or intestinal metaplasia improves after the cure of Helicobacter pylori infection.
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