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Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1
- Tian-tian Wang, F. P. Nestel, +8 authors J. White
- Biology, Medicine
- The Journal of Immunology
- 1 September 2004
The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is an immune system modulator and induces expression of the TLR coreceptor CD14. 1,25(OH)2D3 signals through the vitamin D… Expand
Permeability of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels to Polyatomic Anions
- P. Linsdell, J. Tabcharani, +5 authors J. Hanrahan
- Chemistry, Medicine
- The Journal of general physiology
- 1 October 1997
Permeability of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel to polyatomic anions of known dimensions was studied in stably transfected Chinese hamster ovary cells… Expand
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene
A CYCLIC AMP-stimulated choride conductance appears when the cystic fibres is gene is expressed in non-epithelial cells by infection with recombinant viruses1,2. Cyclic AMP-stimulated conductance in… Expand
Phosphorylation by Protein Kinase C Is Required For Acute Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Protein Kinase A*
Protein kinase A (PKA) stimulates Cl secretion by activating the cystic fibrosis transmembrane conductance regulator (CFTR), a tightly regulated Cl− channel in the apical membrane of many secretory… Expand
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers.
- A. Cantin, J. Hanrahan, +5 authors P. Durie
- American journal of respiratory and critical care…
- 15 May 2006
RATIONALE Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial cells. Oxidants decrease gene expression, protein expression, and function of the cystic fibrosis… Expand
Multi-ion pore behaviour in the CFTR chloride channel
CYSTIC fibrosis transmembrane conductance regulator (CFTR) is a non-rectifying, low-conductance channel1,2 regulated by ATP3 and phosphorylation4, which mediates apical chloride conductance in… Expand
Physiology of epithelial chloride and fluid secretion.
Epithelial salt and water secretion serves a variety of functions in different organ systems, such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the volume… Expand
BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex
BAP31 is an endoplasmic reticulum protein-sorting factor that associates with newly synthesized integral membrane proteins and controls their fate (i.e., egress, retention, survival, or degradation).… Expand
CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli.
Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated ATP efflux has been proposed as an autocrine mechanism for regulating chloride secretion through other types of chloride channels.… Expand
A haplotype-based molecular analysis of CFTR mutations associated with respiratory and pancreatic diseases.
Aberrant membrane transport caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with a wide spectrum of respiratory and digestive diseases as well… Expand