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Basolateral ion transport mechanisms during fluid secretion by Drosophila Malpighian tubules: Na+ recycling, Na+:K+:2Cl– cotransport and Cl– conductance
TLDR
A new model for fluid secretion proposes that K+ and Cl– cross the basolateral membrane through a Na+-driven Na+:K+:2Cl– cotransporter and that most of the Na+ that enters the cells is returned to the bath through the Na-/K+-ATPase.
Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis.
TLDR
It is shown that low levels of VIP and ACh produced significant mucus secretion in human glands via strong synergistic interactions; synergy was lost in glands of CF patients.
Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice
TLDR
A novel defect in local regulation of glands lacking CFTR which may also compromise airway defence in CF patients is revealed.
Intracellular ion activities in Malpighian tubule cells of Rhodnius prolixus: evaluation of Na+-K+-2Cl- cotransport across the basolateral membrane.
TLDR
The results support the involvement of a basolateral Na+-K+-2Cl- cotransporter in serotonin-stimulated fluid secretion by Rhodnius prolixus Malpighian tubules.
Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands
TLDR
Results indicate that SP mediates local responses to capsaicinoids through a mechanism involving coordinated activation of CFTR and K+ channels, and loss of this local regulation in CF may contribute to reduced innate defenses in CF airways.
Effects of cortisol and prolactin on Na+ and Cl- transport in cultured branchial epithelia from FW rainbow trout.
TLDR
Overall, prolactin alone did not appear to promote FW adaptation but exhibited synergism with cortisol, providing further support for the cultured DSI epithelium as an in vitro model for ion transport in FW fish.
Pseudomonas aeruginosa Homoserine Lactone Activates Store-operated cAMP and Cystic Fibrosis Transmembrane Regulator-dependent Cl− Secretion by Human Airway Epithelia*
TLDR
The results suggest that 3O-C12 stimulates CFTR-dependent Cl− and fluid secretion in airway epithelial cells by activating the inositol trisphosphate receptor, thus lowering [Ca2+] in the ER and activating STIM1 and store-operated cAMP production.
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