L 708906

Known as: L 708,906, L-708,906, L-708906 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2011
01220012011

Papers overview

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2011
2011
HIV-1 integrase (IN) has become an attractive target since drug resistance against HIV-1 reverse transcriptase (RT) and protease… (More)
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2009
2009
A three-dimensional model of a complex between HIV-1 integrase (IN), viral DNA, and metal ions that we recently built was used as… (More)
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2008
2008
We have identified 1H-benzylindole analogues as a novel series of human immunodeficiency virus (HIV) integrase inhibitors with… (More)
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2007
2007
We have synthesized novel phosphonic acid analogues of beta-diketo acids. Interestingly, the phosphonic acid isostere, 2, of our… (More)
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2004
2004
OBJECTIVES Study of HIV-1 resistance development to the diketo analogue S-1360, the first HIV-1 integrase strand transfer… (More)
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2003
2003
The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human immunodeficiency… (More)
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2002
2002
Among all the HIV-1 integrase inhibitors, the beta-diketo acids (DKAs) represent a major lead in anti-HIV-1 integrase drug design… (More)
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2002
2002
The 4-aryl-2-hydroxy-4-oxo-2-butenoic acids and their isosteric tetrazoles are among an emerging class of aryl beta-diketo (ADK… (More)
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2002
2002
The insertion of viral DNA into the host chromosome is an essential step in the replication of HIV-1, and is carried out by an… (More)
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2001
2001
To study the effect of potential human immunodeficiency virus type 1 (HIV-1) integrase inhibitors during virus replication in… (More)
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