Skip to search formSkip to main contentSkip to account menu

L 708906

Known as: L 708,906, L-708,906, L-708906 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Acetoacetates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker
Based on the prodrug concept as well as the combination of two different classes of anti-HIV agents, we have designed and… 
Highly Cited
2004
Highly Cited
2004
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
Objectives: Study of HIV-1 resistance development to the diketo analogue S-1360, the first HIV-1 integrase strand transfer… 
Highly Cited
2003
Highly Cited
2003
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).
The beta-diketo acids (DKAs) represent a major advance for anti-HIV-1 integrase drug development. We compared the inhibition of… 
Highly Cited
2003
Highly Cited
2003
Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations
ABSTRACT The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human… 
2002
2002
Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.
Among all the HIV-1 integrase inhibitors, the beta-diketo acids (DKAs) represent a major lead in anti-HIV-1 integrase drug design… 
2002
2002
Structure-based Design of a Novel Peptide Inhibitor of HIV-1 Integrase: A Computer Modeling Approach
Abstract The insertion of viral DNA into the host chromosome is an essential step in the replication of HIV-1, and is carried out… 
2002
2002
Distinct antiviral resistance profiles for three authentic HIV integrase inhibitors L-708,906, S-1360 and V-165
2001
2001
Specific Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Integration in Cell Culture: Putative Inhibitors of HIV-1 Integrase
ABSTRACT To study the effect of potential human immunodeficiency virus type 1 (HIV-1) integrase inhibitors during virus… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)