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L-161982

Known as: L161,982, L 161,982, L-161,982 
National Institutes of Health

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2 relations

Broader (2)

ThiophenesTriazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Identification of the fatty acid activation site on human ClC-2.
Fatty acids (including lubiprostone and cobiprostone) are human ClC-2 (hClC-2) Cl- channel activators. Molecular and cellular… 
2015
2015
Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue[S]
Inflammation of adipose tissue induces metabolic derangements associated with obesity. Thus, determining ways to control or… 
2015
2015
Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
2014
2014
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
2014
2014
Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat
2013
2013
Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY.
Prostaglandins E1 and E2 are synthesized in the intestine and mediate a range of gastrointestinal functions via activation of the… 
2011
2011
Lubiprostone targets prostanoid EP4 receptors in ovine airways
BACKGROUND AND PURPOSE Lubiprostone, a prostaglandin E1 derivative, is reported to activate ClC‐2 chloride channels located in… 
2008
2008
Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2
Objective: To determine the mechanism of matrix metalloproteinase (MMP)-13 upregulation in osteoarthritic synovial fibroblasts… 
Highly Cited
2005
Highly Cited
2005
Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor.
The prostanoid receptors on human airway smooth muscle cells (HASMC) that augment the release by IL-1beta of granulocyte colony… 
2004
2004
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM‐CSF
The prostanoid receptor(s) on human airways smooth muscle (HASM) cells that mediates the inhibitory effect of PGE2 on interleukin… 
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