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L-161982

Known as: L161,982, L 161,982, L-161,982 
National Institutes of Health

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2 relations

Broader (2)

ThiophenesTriazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its… 
2017
2017
Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation
2015
2015
Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue[S]
Inflammation of adipose tissue induces metabolic derangements associated with obesity. Thus, determining ways to control or… 
2011
2011
Lubiprostone targets prostanoid EP4 receptors in ovine airways
BACKGROUND AND PURPOSE Lubiprostone, a prostaglandin E1 derivative, is reported to activate ClC‐2 chloride channels located in… 
2011
2011
Traditional Chinese formula, lubricating gut pill, stimulates cAMP-dependent CI(−) secretion across rat distal colonic mucosa.
Highly Cited
2009
Highly Cited
2009
Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.
BACKGROUND & AIMS Lubiprostone alleviates constipation by stimulating intestinal fluid secretion, purportedly through activation… 
2006
2006
Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity.
Highly Cited
2005
Highly Cited
2005
Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor.
The prostanoid receptors on human airway smooth muscle cells (HASMC) that augment the release by IL-1beta of granulocyte colony… 
2004
2004
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM‐CSF
The prostanoid receptor(s) on human airways smooth muscle (HASM) cells that mediates the inhibitory effect of PGE2 on interleukin… 
Highly Cited
2004
Highly Cited
2004
Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves.
Induction of cyclooxygenase-2 (COX-2) in the renal pelvic wall increases prostaglandin E(2) (PGE(2)) leading to stimulation of… 
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