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Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology
The aim of this article is to outline the rationale for, and the expectations of, the BJP with respect to work published in the Journal that includes immunoblotting or immunohistochemical data and to reduce potential misinterpretations and to maximise the communication and transparency of essential information. Expand
Experimental design and analysis and their reporting: new guidance for publication in BJP
This Editorial is part of a series of editorials based on research published in The Lancet Onlinelibrary.wiley.com/doi/10.1111/bph.13112/abstract. Expand
Pharmacology of the eosinophil.
Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers
The guidelines have been simplified for ease of understanding by authors, to make it more straightforward for peer reviewers to check compliance and to facilitate the curation of the journal's efforts to improve standards. Expand
Prostanoid receptor antagonists: development strategies and therapeutic applications
This review is intended to provide overviews of each antagonist class (including prostamide antagonists), covering major development strategies and current and potential clinical usage. Expand
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2
The ability of rolipram to suppress markedly mitogen‐induced IL‐2 generation without affecting T‐cell proliferation suggests that growth and division of T‐lymphocytes may be governed by mediators in addition to IL‐ 2. Expand
Release of granulocyte‐macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone
  • M. Saunders, Jane A. Mitchell, +4 authors M. Belvisi
  • Biology, Medicine
  • British journal of pharmacology
  • 1 February 1997
The data suggest that human airway smooth muscle cells might play an active part in initiating and/or perpetuating airway inflammation in addition to controlling airway calibre. Expand
Differential Regulation of Cytokine Release and Leukocyte Migration by Lipopolysaccharide-Stimulated Primary Human Lung Alveolar Type II Epithelial Cells and Macrophages1
Activated alveolar epithelium is an important source of chemokines that orchestrate leukocyte migration to the peripheral lung; early release of TNF-α and IL-1β by stimulated macrophages may contribute to alveolars epithelial cell activation and chemokine production. Expand
Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4.
Data confirm the importance of IL-8 and LTB(4) as chemoattractants for neutrophils in bronchial secretions from patients with COPD, and suggest that specific inhibitors may have therapeutic potential in COPD. Expand
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes
Although BRL 50481 had only a modest inhibitory effect per se on the proinflammatory cells studied, it acted at least additively with other cAMP-elevating drugs, especially when HSPDE7A1 was up-regulated. Expand