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Klinefelter Syndrome

Known as: chromosome xxy syndrome, Klinefelter Syndrome [Disease/Finding], klinefelter's syndromes 
A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of… 
National Institutes of Health

Related topics

Related topics

36 relations
46, XX Testicular Disorders of Sex DevelopmentChromosome 13 duplicationChromosome AberrationsEndocrine system

Narrower (3)

48,XXYY Syndrome49,XXXXY SyndromeXXY trisomy

Broader (9)

Congenital chromosomal diseaseDisorder of male reproductive systemFetal DiseasesGenital Diseases, Male

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Recent Progress in Pharmacological Therapy of Male Subfertility — a Review *
Pharmakologische Therapie der Subfertilität des Mannes 
Highly Cited
2000
Highly Cited
2000
Fas and Fas ligand expression in fetal and adult human testis with normal or deranged spermatogenesis.
In mice, the Fas/Fas ligand (FasL) system has been shown to be involved in germ cell apoptosis. In the present study we evaluated… 
Highly Cited
1998
Highly Cited
1998
Germ cell loss in the XXY male mouse: Altered X‐chromosome dosage affects prenatal development
Male mammals with two X chromosomes are sterile due to the demise of virtually all germ cells; however, the underlying reasons… 
Review
1986
Review
1986
Comparison of the potential for therapeutic utilities with gonadotropin-releasing hormone agonists and antagonists.
Introduction THE SUCCESS in synthesis of very potent agonistic analogs of GnRH was at first expected to lead to a low cost… 
Highly Cited
1982
Highly Cited
1982
Hypogonadism in male patients with metastatic cancer prior to chemotherapy.
Gonadal hormonal function was assessed in 44 adult males with disseminated cancer prior to chemotherapeutic treatment of their… 
Highly Cited
1979
Highly Cited
1979
The Aicardi Syndrome in a 47, XXY Male
Hopkins, I. J., Humphrey, I., Keith, C. G., Susman, M., Webb, G. C. and Turner, E. K. (1979). Aust. Paediatr. J., 278–280. the… 
Review
1976
Review
1976
Edward T. Tyler Prize Oration: LH-releasing hormone and its analogues: recent basic and clinical investigations.
Literature on luteinizing hormone-releasing hormone (LH-RH) and its analogues is reviewed. LH-RH, which stimulates the release… 
Highly Cited
1973
Highly Cited
1973
Heterogeneity of gonadotropin response to LHRH in hypogonadotropic hypogonadism.
A group of six hypogonadal males with low serum levels of FSH and LH, and otherwise normal pituitary function, underwent tests in… 
Highly Cited
1970
Highly Cited
1970
Simian papovavirus 40 transformation of cells from cancer patient with XY-XXY mosaic Klinefelter's syndrome.
Summary Transformation frequency by simian papovavirus 40 of fibroblasts from a lung cancer patient with Klinefelter9s syndrome… 
Review
1967
Review
1967
Three cases of triploidy in man.
A premature baby of 32 weeks gestation and weighing 1.7 kg (3 lb 12 oz), with a defect in each iris and anomalous genitalia… 
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