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Ketotifen

Known as: 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, Ketotifene, Ketotiphen 
A cycloheptathiophene derivative with anti-allergic activity. Ketotifen selectively blocks histamine (H1) receptors and prevents the typical symptoms… Expand
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Mast cell stabilizing drugs inhibit the release of allergic mediators from mast cells and are used clinically to prevent allergic… Expand
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Highly Cited
2010
Highly Cited
2010
Background Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics of the… Expand
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2010
2010
Obesity is a major health problem world-wide. Medical intervention is often needed to tackle this problem, and accordingly the… Expand
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Highly Cited
2006
Highly Cited
2006
Despite intensive research, the mechanisms by which vesicular systems deliver drugs into intact skin are not yet fully understood… Expand
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Highly Cited
2001
Highly Cited
2001
The in vivo metabolism of three pharmaceutical compounds, EMD68843, EMD96785, and EMD128130, was compared in fresh and… Expand
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Highly Cited
1996
Highly Cited
1996
Background A comprehensive comparative study of the central nervous system (CNS) properties of newer H1‐receptor antagonists is… Expand
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Highly Cited
1995
Highly Cited
1995
Recent studies have suggested that nitric oxide (NO.), the product of nitric oxide synthase in inflammatory cells, may play a… Expand
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Highly Cited
1993
Highly Cited
1993
Recent work has demonstrated that inhibition of nitric oxide production with various nitric oxide synthesis inhibitors (l‐NAME, l… Expand
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Highly Cited
1992
Highly Cited
1992
To evaluate the prophylactic effect of ketotifen against the onset of asthma we selected 121 infants with atopic dermatitis… Expand
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Review
1989
Review
1989
Since the pharmacological treatment of allergic diseases is used in patients with alteration of the immune response due to atopy… Expand
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