Ketamine

Known as: Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-, Ketaminum, Ketamine [Chemical/Ingredient] 
A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts… (More)

Topic mentions per year

Topic mentions per year

1967-2017
0500100019672017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
BACKGROUND Ketamine exerts a robust, rapid, and relatively sustained antidepressant effect in patients with major depression… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
This study evaluates the effects of ketamine on healthy and schizophrenic volunteers (SVs) in an effort to define the detailed… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
BACKGROUND A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
N-methyl-D-aspartate (NMDA) glutamate receptor antagonists are reported to induce schizophrenia-like symptoms in humans… (More)
  • figure 2
  • figure 1
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. We administered… (More)
  • table 1
  • table 2
  • figure 1
  • figure 1
Is this relevant?
Highly Cited
1996
Highly Cited
1996
A rapidly growing body of preclinical data has implicated the glutamatergic N-methyl-d-aspartate (NMDA) receptor in memory and… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
We administered ketamine to schizophrenic individuals in a double-blind, placebo-controlled design using a range of subanesthetic… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
BACKGROUND To characterize further behavioral, cognitive, neuroendocrine, and physiological effects of subanesthetic doses of… (More)
Is this relevant?
Highly Cited
1989
Highly Cited
1989
To develop a simple, relatively noninvasive small-animal model of reversible regional cerebral ischemia, we tested various… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
Is this relevant?