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Ketamine

Known as: Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-, Ketaminum, Ketamine [Chemical/Ingredient] 
A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (6)

6-hydroxyketamine6-hydroxynorketamineKetalarKetamine Hydrochloride

Broader (7)

AnalgesicsAnestheticsAnesthetics, DissociativeCyclohexane
AneurysmAngina PectorisCongestive heart failureGeneral Anesthesia [PE]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology
Preclinical studies suggest that ketamine-induced psychopathology is mediated, in part, by increased glutamate release… 
Highly Cited
2000
Highly Cited
2000
Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine
Background It has been reported that &mgr;-opioid receptor activation leads to a sustained increase in glutamate synaptic… 
Highly Cited
1999
Highly Cited
1999
Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia.
OBJECTIVE This study sought to determine whether thought disorder induced in healthy volunteers by the N-methyl-D-aspartic acid… 
Highly Cited
1998
Highly Cited
1998
Psychedelic Effects of Ketamine in Healthy Volunteers: Relationship to Steady‐state Plasma Concentrations
Background Ketamine has been associated with a unique spectrum of subjective “psychedelic” effects in patients emerging from… 
Highly Cited
1995
Highly Cited
1995
Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia
Highly Cited
1995
Highly Cited
1995
Ketamine activates psychosis and alters limbic blood flow in schizophrenia
The non-competitive NMDA antagonist ketamine, given to schizophrenic individuals in subanesthetic doses, produced a short-lived… 
Highly Cited
1992
Highly Cited
1992
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
The chiral forms of ketamine were applied as probes for N-methyl-D-aspartate receptor-mediated neurotransmission in humans. Both… 
Review
1989
Review
1989
Ketamine: an update on the first twenty-five years of clinical experience
RésuméPendant presque 25 ans ďexpérience clinique, les bénéfices et les limitations de ľanesthésie à la kétamine ont été gén… 
Highly Cited
1987
Highly Cited
1987
Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat
Highly Cited
1982
Highly Cited
1982
Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans.
The pharmacokinetics of ketamine in analgesic doses after intravenous, intramuscular, and oral administration was investigated in… 
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