Ketamine Hydrochloride

Known as: Ketamine HCl, Ketamine Hydrochloride [Chemical/Ingredient] 
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Although the efficacy of racemate ketamine, a rapid onset and sustained antidepressant, for patients with treatment-resistant… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND The N-methyl-D-aspartate glutamate receptor antagonist ketamine, delivered via an intravenous route, has shown rapid… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant… (More)
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Highly Cited
2010
Highly Cited
2010
CONTEXT Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that… (More)
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Highly Cited
2008
Highly Cited
2008
CONTEXT Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND A growing body of preclinical research suggests that brain glutamate systems may be involved in the pathophysiology of… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND This study evaluated the dose-related ethanol-like subjective effects of the N-methyl-D-aspartate (NMDA) glutamate… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND To characterize further behavioral, cognitive, neuroendocrine, and physiological effects of subanesthetic doses of… (More)
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