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An emergent model of orientation selectivity in cat visual cortical simple cells
A 1:4 scale model of a 1700 microns by 200 microms region of layer IV of cat primary visual cortex is presented to demonstrate that local intracortical excitation may provide the dominant source of orientation-selective input and provide a unified account of intracellular and extracellular inhibitory blockade experiments that had previously appeared to conflict over the role of inhibition.
Adaptation-Induced Plasticity of Orientation Tuning in Adult Visual Cortex
Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation
Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex
Two-photon imaging of calcium signals in the ferret visual cortex in vivo is used to discover that astrocytes respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency.
Division and subtraction by distinct cortical inhibitory networks in vivo
A new platform for two-way light-based circuit interrogation in visual cortex in vivo is used to show the computational implications of modulating different subclasses of inhibitory neurons during sensory processing, finding that soma-targeting, parvalbumin-expressing (PV) neurons principally divide responses but preserve stimulus selectivity.
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
- D. Tropea, E. Giacometti, M. Sur
- BiologyProceedings of the National Academy of Sciences
- 10 February 2009
Systemic treatment of MeCP2 mutant mice with an active peptide fragment of Insulin-like Growth Factor 1 (IGF-1) extends the life span of the mice, improves locomotor function, ameliorates breathing patterns, and reduces irregularity in heart rate.
Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
It is demonstrated that AAV-mediated SpCas9 genome editing can enable reverse genetic studies of gene function in the brain and characterized the effects of genome modifications in postmitotic neurons using biochemical, genetic, electrophysiological and behavioral readouts.
Patterning and Plasticity of the Cerebral Cortex
The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into discrete subdivisions or areas that process particular aspects of sensation, movement, and cognition. Recent…
Representations of the body surface in postcentral parietal cortex of Macaca fascicularis
- R. Nelson, M. Sur, D. Felleman, J. Kaas
- Biology, MedicineThe Journal of comparative neurology
- 15 August 1980
The somatotopic organization of the postcentral parietal cortex of the Old World monkey, Macaca fascicularis, was determined with multi‐unit microelectrode recordings and it is suggested that the representation in Area 3b is homologous to “SmI” (or “SI”) in non‐primates.