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KW 2149
Known as:
KW-2149
A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Antibiotics, Antineoplastic
Mitomycins
KT 6149
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Advances in Brief Induction of Protein-DNA Complexes in HeLa $ 3 Cells by KW-2149 , a New Derivative of Mitomycin C
2007
Corpus ID: 42277675
KW-2149 is a new water-soluble analogue of mitomycin C which shows a broad spectrum antitumor activity in experimental tumor…
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2004
2004
Disposition and metabolism of KW-2149, a novel anticancer agent
S. Kobayashi
,
J. Ushiki
,
+7 authors
Tadashi Hirata
Cancer Chemotherapy and Pharmacology
2004
Corpus ID: 27440416
KW-2149 is a new derivative of mitomycin C (MMC). The plasma concentrations, distribution, metabolism, and excretion of [3H]-KW…
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2001
2001
Circumvention of glutathione-mediated mitomycin C resistance by a novel mitomycin C ancalogue,KW-2149
石田 智之
2001
Corpus ID: 87168252
2000
2000
Inhibitory effects of subcutaneous dexamethasone treatment on rat pulmonary toxicity of KW-2149, a new mitomycin C analogue
K. Takaba
,
H. Furumoto
,
+4 authors
Akio Ishii
Archives of Toxicology
2000
Corpus ID: 21236111
Abstract An experimental model for pulmonary toxicity of KW-2149, a new mitomycin C analogue, was established and the inhibitory…
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1999
1999
21D-03-5 Effects of Restricted Water Intake and the Administration of Furosemide, BSO and BHA on Pulmonary Toxicity of KW-2149 (Mitomycin C Analog).
F. Furukawa
,
A. Nishikawa
,
+4 authors
M. Hirose
1999
Corpus ID: 83130094
1998
1998
Inhibitory effects of dexamethasone on pulmonary toxicity of a new mitomycin C analogue KW-2149 in a novel rat model.
T. Harada
,
K. Takaba
,
+4 authors
Akio Ishii
1998
Corpus ID: 83215455
1995
1995
Phase I and pharmacokinetic study of a novel mitomycin C analog KW‐2149
L. Dirix
,
G. Catimel
,
+9 authors
A. V. van Oosterom
Anti-Cancer Drugs
1995
Corpus ID: 13588465
KW-2149 is a new, semisynthetic, C-7-N-substituted, mitomycin C (MMC) analog showing equal or superior anti-tumor activity in…
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1993
1993
Reduced bone marrow toxicity of KW‐2149, a mitomycin C derivative, in mice
T. Ashizawa
,
M. Okabe
,
K. Gomi
,
T. Hirata
Anti-Cancer Drugs
1993
Corpus ID: 25312155
The bone marrow toxicity of KW-2149, a newly synthesized mitomycin C (MMC) derivative, was compared with MMC in different aged…
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1989
1989
Synthesis of mitomycin derivatives with disulfide at the 7-N side chain (3): synthesis of KW 2149 and structure-activity relationships among mitomycin derivatives with disulfide at the 7-N side chain
M. Kono
,
Y. Saitoh
,
+4 authors
T. Ashizawa
1989
Corpus ID: 83207672