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KW 2149

Known as: KW-2149 
A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes… 
National Institutes of Health

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3 relations

Broader (2)

Antibiotics, AntineoplasticMitomycins
KT 6149

Papers overview

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2005
2005
7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin.
Dimeric alkylating agents that modify complementary DNA strands have engendered significant interest. We have prepared the novel… 
2004
2004
Comparison of uptake of mitomycin C and KW-2149 by murine P388 leukemia cells sensitive or resistant to mitomycin C
SummaryKW-2149, a new mitomycin C (MMC) derivative, inhibited the growth of murine P388 leukemia in vitro at 20-fold lower… 
2004
2004
Disposition and metabolism of KW-2149, a novel anticancer agent
KW-2149 is a new derivative of mitomycin C (MMC). The plasma concentrations, distribution, metabolism, and excretion of [3H]-KW… 
2004
2004
Antitumor activity of a derivative of mitomycin, 7-N-[2-[[2-(γ-l-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149), against murine and human tumors and a mitomycin C-resistant tumor in vitro and…
SummaryThe antitumor activity of a mitomycin derivative, 7-N-[2-[[2-(γ-glutamylamino)ethyl]dithio]ethyl]mitomycin C (KW-2149… 
1995
1995
Isolation of albomitomycins from solutions of 7-amino substituted mitomycins; mitomycin C and KW-2149.
investigation of new potent analogs with less toxicity has been active1} and we have found a new promising clinical candidate of… 
1995
1995
Phase I and pharmacokinetic study of a novel mitomycin C analog KW‐2149
KW-2149 is a new, semisynthetic, C-7-N-substituted, mitomycin C (MMC) analog showing equal or superior anti-tumor activity in… 
1995
1995
Characteristics of the antitumor activity of M-16 and M-18, major metabolites of a new mitomycin C derivative KW-2149, in mice.
The cell growth inhibitory activity, antitumor activity and toxicity of M-16 and M-18, the major metabolites of a new mitomycin C… 
1994
1994
Cytotoxic activity of 7-N-(2-((2-(-gamma-L-glutamylamino)- ethyl)dithio)ethyl)-mitomycin C and metabolites in cell lines with different resistance patterns.
In this study the activity of KW-2149 and two of its metabolites, M-16 and M-18, was measured against cell lines with different… 
1994
1994
Nonenzymatic reductive activation of 7-N-((2-([2-(gamma-L-glutamylamino)ethyl]dithio)ethyl))mitomycin C by thiol molecules: a novel mitomycin C derivative effective on mitomycin C-resistant tumor…
7-N-((2-([2-(gamma-L-Glutamylamino)ethyl]dithio)ethyl))mitomycin C (KW-2149) is an analogue of mitomycin C (MMC) and has… 
1993
1993
Reduced bone marrow toxicity of KW‐2149, a mitomycin C derivative, in mice
The bone marrow toxicity of KW-2149, a newly synthesized mitomycin C (MMC) derivative, was compared with MMC in different aged… 
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