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Identification of Ras farnesyltransferase inhibitors by microbial screening.
TLDR
Kinetic analyses of the inhibition suggest that UCF1-C shows significant activity to inhibit the growth of Ki-ras-transformed fibrosarcoma, raising the possibility of its use as an antitumor drug. Expand
A rhodopsin is the functional photoreceptor for phototaxis in the unicellular eukaryote Chlamydomonas
TLDR
It is shown here that the unicellular alga Chlamydomonas does indeed use a rhodopsin photoreceptor, and that 11-cis-retinal is the natural chromophore and that the protein environment of this retinal is similar to that found in bovine rhodopin, suggesting homology with the r Rhodopsins of higher organisms. Expand
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
TLDR
Results imply that UCN-01 is a promising antitumor agent which has a novel mechanism(s), of action, which has some aberrations in cellular signal transduction. Expand
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma
TLDR
Results suggest that G1-phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitors p21 and p27. Expand
Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein.
TLDR
Elevated neutrophil levels can be maintained for extended periods following single administration of high-molecular-weight PEG-NTG, and increasing the extent of PEGylation also increases in vivo activity. Expand
Antitumor activity of KW‐2170, a novel pyrazoloacridone derivative
TLDR
KW-2170 has a very potent antitumor activity and is feasible as a new antitumors drug against ADM-refractory solid tumors in clinics, and the drug showed significant antitUMor activity against ADm-resistant human ovary carcinoma A2780/ADM and against nasopharynx carcinoma KB-A1 xenografts which were not sensitive to ADM. Expand
Mutagenesis of human granulocyte colony stimulating factor.
TLDR
A number of mutants of human granulocyte colony-stimulating factor made by in vitro mutagenesis showed more potent granulopoietic activity than that of intact hG-CSF both in vitro and in vivo. Expand
Metabolism and ribonucleotide reductase inhibition of (E  )-2′-deoxy-2′-(fluoromethylene)cytidine, MDL 101,731, in human cervical carcinoma HeLa S3 cells
TLDR
It is suggested that the prolonged ribonucleotide reductase inhibition by rapidly activated metabolites of MDL 101,731 in part contributes to the potent antitumor activity of this drug against various xenografts. Expand
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
TLDR
The results suggests the feasibility of using UCN-01 in clinical oncology, especially in combination with alkylating agents such as MMC, which might be a novel chemotherapeutic approach to MMC-insensitive tumors in clinical trials. Expand
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