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KSR1 gene

Known as: RSU2, KINASE SUPPRESSOR OF RAS 1, KSR1 
This gene plays a role in cell growth and differentiation.
National Institutes of Health

Related topics

Related topics

5 relations
KSR protein, humanKSR1 wt AlleleKinase suppressor of ras-1 proteinSerine/Threonine Phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.
Endothelin (ET)-1 is a likely candidate for a key role in diabetic vascular complications. In the present study, we hypothesized… 
2011
2011
KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.
2011
2011
Regulation of Glucose Homeostasis by KSR1 and MARK2
Protein scaffolds control the intensity and duration of signaling and dictate the specificity of signaling through MAP kinase… 
2010
2010
Pharmacologic Inactivation of Kinase Suppressor of Ras1 Sensitizes Epidermal Growth Factor Receptor and Oncogenic Ras-Dependent Tumors to Ionizing Radiation Treatment
Selective enhancement of tumor response to radiation therapy is a highly attractive objective, but it has not been met clinically… 
2010
2010
Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection
The scaffold protein kinase suppressor of Ras 1 (KSR1) is critical for efficient activation of ERK in a number of cell types… 
2009
2009
A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation
Genetic and biochemical data support Kinase Suppressor of Ras 1 (KSR1) as a positive regulator of the Ras-Raf-MAPK pathway… 
2009
2009
Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines
Previous studies have indicated that the ERK1/2 MAP kinase signaling pathway plays an important role not only in cell growth… 
2008
2008
Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotides correlates with tumor drug uptake
While antisense oligonucleotide (AS-ODN) technology holds promise for the treatment of cancer, to date there have been no… 
2007
2007
Role of Kinase Suppressor of Ras-1 in Neuronal Survival Signaling by Extracellular Signal-Regulated Kinase 1/2
Scaffolding proteins including kinase suppressor of Ras-1 (KSR1) determine specificity of signaling by extracellular signal… 
2007
2007
Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1*♦
Kinase suppressor of Ras 1 (KSR1) is a protein scaffold that facilitates ERK cascade activation at the plasma membrane, a… 
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