• Publications
  • Influence
Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
BACKGROUND & AIMS Increased inflammatory cytokine levels and intestinal epithelial cell apoptosis leading to disruption of epithelial integrity are major pathologic factors in inflammatory bowelExpand
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Recurrent Abdominal Pain: Symptom Subtypes Based on the Rome II Criteria for Pediatric Functional Gastrointestinal Disorders
Objectives Recurrent abdominal pain (RAP) is a common childhood complaint rarely associated with organic disease. Recently, the Pediatric Rome Criteria were developed to standardize theExpand
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Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells*
  • F. Yan, D. Polk
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 27 December 2002
Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating disease. However, little information is known regarding the scientific rationale for using probiotics asExpand
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Helicobacter pylori: gastric cancer and beyond
Helicobacter pylori is the dominant species of the human gastric microbiome, and colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the strongest singular riskExpand
  • 691
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Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.
Probiotics promote intestinal epithelial integrity and reduce infection and diarrhea. We evaluated the effect of Lactobacillus rhamnosus GG-produced soluble proteins (p40 and p75) on the hydrogenExpand
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Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line.
BACKGROUND & AIMS Tumor necrosis factor (TNF)-alpha is a prominent cytokine in the pathogenesis of inflammatory bowel disease, yet its effects on the intestinal epithelium remain poorly understood.Expand
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Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity.
  • D. Polk
  • Biology, Medicine
  • Gastroenterology
  • 1 March 1998
BACKGROUND & AIMS Ulceration of intestinal mucosa is rapidly followed by enterocyte migration via restitution. The aim of this study was to investigate signaling mechanisms of epidermal growth factorExpand
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Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
Probiotic bacteria can potentially have beneficial effects on the clinical course of several intestinal disorders, but our understanding of probiotic action is limited. We have identified a probioticExpand
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Regulation of apoptosis during homeostasis and disease in the intestinal epithelium.
A single epithelial layer serves as the interface between the organism and the contents of the gastrointestinal tract, underlining the importance of regulating cellular viability despite an onslaughtExpand
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Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
BACKGROUND & AIMS Helicobacter pylori infection disrupts the balance between gastric epithelial cell proliferation and apoptosis, which is likely to lower the threshold for the development of gastricExpand
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