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KLKB1 gene

Known as: PKK, Kallikrein B, Plasma (Fletcher Factor) 1 Gene, KLK3, FORMERLY 
This gene plays a role in proteolytic processing.
National Institutes of Health

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Blood coagulationHydrolysisKLK3 geneKLK3 wt Allele

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KLKB1 wt Allele

Papers overview

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Highly Cited
2004
Highly Cited
2004
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… 
Highly Cited
2002
Highly Cited
2002
Identification and Characterization of Prolylcarboxypeptidase as an Endothelial Cell Prekallikrein Activator*
Our recent investigations have postulated a human umbilical vein endothelial cell (HUVEC)-associated prekallikrein activator (PKA… 
Highly Cited
1997
Highly Cited
1997
Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor.
Highly Cited
1978
Highly Cited
1978
Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII).
The mechanism by which negatively charged substances such as celite, kaolin, or ellagic acid contribute to the surface-dependent… 
Highly Cited
1978
Highly Cited
1978
Hypotension associated with prekallikrein activator (Hageman-factor fragments) in plasma protein fraction.
Thirteen lots of plasma protein fraction made by one manufacturer were implicated in 23 recent reports of hypotension in surgical… 
Review
1978
Review
1978
Determination of prekallikrein in human plasma: optimal conditions for activating prekallikrein.
A method for the assay of human plasma prekallikrein in which a chromogenic synthetic tripeptide, PPAN, is used as a substrate… 
Highly Cited
1977
Highly Cited
1977
Association of factor XI and high molecular weight kininogen in human plasma.
Factor XI and high molecular weight kininogen were found associated in normal human plasma at mol wt 380,000 as assessed by gel… 
Highly Cited
1977
Highly Cited
1977
Hageman factor substrates. Human plasma prekallikrein: mechanism of activation by Hageman factor and participation in hageman factor-dependent fibrinolysis.
Highly Cited
1973
Highly Cited
1973
PREKALLIKREIN DEFICIENCY IN MAN
Blood plasma obtained from an individual with abnormal thromboplastin formation, due to deficiency of Fletcher factor, was fully… 
Highly Cited
1970
Highly Cited
1970
A pre-albumin activator of prekallikrein.
Chromatography of human serum on diethylaminoethyl cellulose reveals five peaks having bradykinin-generating activity… 
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