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KLKB1 gene

Known as: PKK, Kallikrein B, Plasma (Fletcher Factor) 1 Gene, KLK3, FORMERLY 
This gene plays a role in proteolytic processing.
National Institutes of Health

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Blood coagulationHydrolysisKLK3 geneKLK3 wt Allele

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KLKB1 wt Allele

Papers overview

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Review
2007
Review
2007
Fifty years of research on the plasma kallikrein-kinin system: From protein structure and function to cell biology and in-vivo pathophysiology
Fifty years of research on the plasma kallikrein-kinin system: From protein structure and function to cell biology and in-vivo… 
Highly Cited
1999
Highly Cited
1999
Identification of Amino Acids in the Factor XI Apple 3 Domain Required for Activation of Factor IX*
Activated coagulation factor XI (factor XIa) proteolytically cleaves its substrate, factor IX, in an interaction requiring the… 
Review
1999
Review
1999
Biologic Activities of the Contact Factors In Vivo
Three plasma proteins, namely, Factor XII (Hageman factor), prekallikrein (Fletcher factor), and high molecular weight kininogen… 
Highly Cited
1998
Highly Cited
1998
A Binding Site for Heparin in the Apple 3 Domain of Factor XI*
Since heparin potentiates activated factor XI (FXIa) inhibition by protease nexin-2 by providing a template to which both… 
Highly Cited
1980
Highly Cited
1980
Immunochemical studies of human high molecular weight kininogen and of its complexes with plasma prekallikrein or kallikrein.
Human plasm contains at least two distinct kininogens, designated high Mr and low Mr kininogens, that differ in their Mr and… 
Highly Cited
1979
Highly Cited
1979
Initiation of plasma prorenin activation by Hageman factor-dependent conversion of plasma prekallikrein to kallikrein.
Plasma prorenin is an inactive form of renin (EC 3.4.99.19) that can be converted to active renin in acid-treated plasma by an… 
Review
1978
Review
1978
Determination of prekallikrein in human plasma: optimal conditions for activating prekallikrein.
A method for the assay of human plasma prekallikrein in which a chromogenic synthetic tripeptide, PPAN, is used as a substrate… 
Highly Cited
1977
Highly Cited
1977
The binding and cleavage characteristics of human Hageman factor during contact activation. A comparison of normal plasma with plasmas deficient in factor XI, prekallikrein, or high molecular weight…
The ability of human Hageman factor (coagulation factor XII) to bind to a glass surface and its susceptibility to limited… 
Highly Cited
1973
Highly Cited
1973
PREKALLIKREIN DEFICIENCY IN MAN
Blood plasma obtained from an individual with abnormal thromboplastin formation, due to deficiency of Fletcher factor, was fully… 
Highly Cited
1969
Highly Cited
1969
Studies on the prekallikrein (kallikreinogen)--kallikrein enzyme system of human plasma. I. Isolation and purification of plasma kallikreins.
By measurement of its arginine esterase activity, plasma kallikrein was purified from fresh frozen ACD plasma. The steps involved… 
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