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KDM6A gene

Known as: UTX, Lysine (K)-Specific Demethylase 6A Gene, lysine demethylase 6A 
This gene is involved in the modulation of histone methylation.
National Institutes of Health

Related topics

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4 relations

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KDM6A wt AlleleLysine-Specific Demethylase 6A
Oxidation-ReductionUtx protein, mouse

Papers overview

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2019
2019
MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia
Cancer genome sequencing studies have focused on identifying oncogenic mutations. However, mutational profiling alone may not… 
2019
2019
Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells
Although the methylation status of histone H3K27 plays a critical role in CD4+ T cell differentiation and its function, the role… 
2018
2018
Anatomical and functional abnormalities on MRI in kabuki syndrome
Review
2016
Review
2016
The Roles of Histone Demethylase UTX and JMJD3 (KDM6B) in Cancers: Current Progress and Future Perspectives.
Aberrant epigenetic reprogramming occurs frequently in the development of tumors. Histone H3 lysine 27 trimethylation (H3K27me3… 
Review
2014
Review
2014
Molecular basis for substrate recognition by lysine methyltransferases and demethylases.
2014
2014
Role of UTX in Retinoic Acid Receptor-Mediated Gene Regulation in Leukemia
ABSTRACT Human UTX, a member of the Jumonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes… 
2014
2014
Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells
Arachidonate 15-lipoxygenase-1 (ALOX15) oxygenates polyunsaturated fatty acids and bio-membranes, generating multiple lipid… 
Highly Cited
2012
Highly Cited
2012
Enhancer-associated H 3 K 4 monomethylation by Trithorax-related , the Drosophila homolog of mammalian Mll 3 / Mll 4
Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys 27 (H3K27ac) are histone modifications that… 
2010
2010
Tumor suppression by the histone demethylase UTX
Comment on: Wang JK, et al. Genes Dev 2010; 24:327-32. 
2006
2006
Fast and non-invasive PCR sexing of primates: apes, Old World monkeys, New World monkeys and Strepsirrhines
BackgroundOne of the key tools for determining the social structure of wild and endangered primates is the ability to sex DNA… 
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