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Lysine-Specific Demethylase 6A

Known as: KDM6A protein, human, EC 1.14.11.-, UTX protein, human 
Lysine-specific demethylase 6A (1401 aa, ~154 kDa) is encoded by the human KDM6A gene. This protein is involved in the demethylation of histone H3.
National Institutes of Health

Related topics

Related topics

12 relations
Cell NucleusEnzyme GeneHistone Demethylase JMJD3KDM5A gene

Broader (2)

Histone DemethylasesNuclear Proteins

Papers overview

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2019
2019
Abstract C22: Loss of KDM6A promotes pancreatic cancer progression by upregulating epithelial-mesenchymal transition pathway
Metastasis is one of the main reasons for poor survival in patients with pancreatic ductal adenocarcinoma (PDA). However, the… 
2019
2019
Mutation of KDM6A Gene in Relapsed Acute Myeloid Leukemia
With the exception of bladder cancer, the frequency of KDM6A gene mutations in malignancy is thought to be rather low in… 
2018
2018
Role of the histone demethylase KDM6A in pancreatic cancer
2018
2018
KDM6A Loss Induces Aggressive Pancreatic Cancer in Mice.
Loss of the X chromosome-encoded KDM6A aberrantly activates oncogenic superenhancers. 
2017
2017
HISTONE LYSINE DEMETHYLASE KDM6A INHIBITOR ALLEVIATES OSTEOARTHRITIS
Background Epigenetic regulation of gene transcription affects metabolism of chondrocytes and synovial fibroblasts and is… 
2017
2017
KDM6 enzymes as drug targets in inflammation
The inflammatory disease Rheumatoid Arthritis (RA) is a severe illness and there is urgent need for new drugs to supplement… 
2015
2015
Clinical findings in patients with RAP 1 A / RAP 1 B mutations Symptom Frequency in KSA RAP 1 A patient RAP 1
3 5 8 5 jci.org Volume 125 Number 9 September 2015 Introduction De novo dominant germline mutations in lysine (K)–specific…