Skip to search formSkip to main contentSkip to account menu

Lysine-Specific Demethylase 6A

Known as: KDM6A protein, human, EC 1.14.11.-, UTX protein, human 
Lysine-specific demethylase 6A (1401 aa, ~154 kDa) is encoded by the human KDM6A gene. This protein is involved in the demethylation of histone H3.
National Institutes of Health

Related topics

Related topics

12 relations
Cell NucleusEnzyme GeneHistone Demethylase JMJD3KDM5A gene

Broader (2)

Histone DemethylasesNuclear Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
A KDM6A–KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction
Diabetic nephropathy is the leading cause of end‐stage renal disease. Although dysfunction of podocytes, also termed glomerular… 
Review
2019
Review
2019
The histone demethylase UTX/KDM6A in cancer: Progress and puzzles
The lysine‐specific demethylase 6A/UTX (gene name KDM6A) acts as a component of the COMPASS complex to control gene activation… 
Highly Cited
2018
Highly Cited
2018
Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
Purpose: To investigate genomic differences between urothelial carcinomas of the upper tract (UTUC) and bladder (UCB), with a… 
Highly Cited
2016
Highly Cited
2016
Multiplex PCR and Next Generation Sequencing for the Non-Invasive Detection of Bladder Cancer
Background Highly sensitive and specific urine-based tests to detect either primary or recurrent bladder cancer have proved… 
Highly Cited
2016
Highly Cited
2016
An essential role for UTX in resolution and activation of bivalent promoters
Trimethylated histone H3 lysine 27 (H3K27me3) is linked to gene silencing, whereas H3K4me3 is associated with gene activation… 
Highly Cited
2014
Highly Cited
2014
Molecular Analysis, Pathogenic Mechanisms, and Readthrough Therapy on a Large Cohort of Kabuki Syndrome Patients
Kabuki syndrome (KS) is a multiple congenital anomalies syndrome characterized by characteristic facial features and varying… 
Highly Cited
2014
Highly Cited
2014
Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy
Although urothelial carcinoma (UC) of the urinary bladder generally portends a favorable prognosis, metastatic tumors often… 
Highly Cited
2014
Highly Cited
2014
Whole-Exome Sequencing of Muscle-Invasive Bladder Cancer Identifies Recurrent Mutations of UNC5C and Prognostic Importance of DNA Repair Gene Mutations on Survival
Purpose: Because of suboptimal outcomes in muscle-invasive bladder cancer even with multimodality therapy, determination of… 
Review
2012
Review
2012
Epigenetic regulation in RCC: opportunities for therapeutic intervention?
Renal cell carcinoma (RCC) is a constellation of malignancies of different histological subtypes arising from the renal… 
Highly Cited
2011
Highly Cited
2011
Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes
ABSTRACT A number of epigenetic alterations occur in both the virus and host cellular genomes during human papillomavirus (HPV… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)