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The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.
TLDR
The most complete human lncRNA annotation to date is presented, produced by the GENCODE consortium within the framework of the ENCODE project and comprising 9277 manually annotated genes producing 14,880 transcripts, and expression correlation analysis indicates that lncRNAs show particularly striking positive correlation with the expression of antisense coding genes.
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
TLDR
It is shown that TRBP, which contains three double-stranded, RNA-binding domains, is an integral component of a Dicer-containing complex, and depletion of the Dicer–TRBP complex via exogenously introduced siRNAs diminished RISC-mediated reporter gene silencing.
The Microprocessor complex mediates the genesis of microRNAs
TLDR
In vivo knock-down and in vitro reconstitution studies revealed that both components of this smaller complex, termed Microprocessor, are necessary and sufficient in mediating the genesis of miRNAs from the primary miRNA transcript.
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
TLDR
In vitro reconstitution of the BHC complex using recombinant subunits reveals an essential role for the REST corepressor CoREST, not only in stimulating dem methylation on core histones but also promoting demethylation of nucleosomal substrates.
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
TLDR
It is shown that human UTX, a member of the Jumonji C family of proteins, is a di- and trimethyl H3K27 demethylase, and a concerted mechanism for transcriptional activation in which cycles of H3k4 methylation by MLL2/3 are linked with the demethylation of H 3K27 through UTX.
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
TLDR
This work reports the isolation of a novel SMRT-containing complex from HeLa cells that contains transducin beta-like protein 1 (TBL1), whose gene is mutated in human sensorineural deafness and contains HDAC3, a histone deacetylase not previously thought to interact with SMRT.
An operational definition of epigenetics.
TLDR
It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype.
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