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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
TLDR
T tandem affinity purification was used to process 4,562 different tagged proteins of the yeast Saccharomyces cerevisiae to identify protein–protein interactions, which will help future studies on individual proteins as well as functional genomics and systems biology.
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The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis.
TLDR
The process of histone H2B monoubiquitination-dependent and -independent hist one H3K4 methylation as a mark of active transcription, enhancer signatures, and developmentally poised genes is discussed and recent findings in this regard are examined.
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Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8.
TLDR
The results suggest that the histone H2B ubiquitylation state is dynamic during transcription, and that the sequence of histone modifications helps to control transcription.
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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
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Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.
TLDR
The recent biochemical, molecular, cellular, and physiological functions of histone methylation and ubiquitination involved in the regulation of gene expression as determined by a combination of enzymological, structural, and genetic methodologies are highlighted.
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RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach
TLDR
To physically characterize the web of interactions connecting the Saccharomyces cerevisiae proteins suspected to be RNA polymerase II elongation factors, subunits of Spt4/Spt5 and Spt16/Pob3 were affinity purified under conditions designed to minimize loss of associated polypeptides and then identified by mass spectrometry.
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New Nomenclature for Chromatin-Modifying Enzymes
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The Paf1 Complex Is Essential for Histone Monoubiquitination by the Rad6-Bre1 Complex, Which Signals for Histone Methylation by COMPASS and Dot1p*
TLDR
In addition to its role during the elongation phase of transcription, the Paf1 complex appears to activate the function but not the placement of the Rad6-Bre1 ubiquitin-protein ligase at the promoters of active genes.
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Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
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An operational definition of epigenetics.
TLDR
It was evident that multiple mechanistic steps lead to the stable heritance of the epigenetic phenotype.
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