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K-562

Known as: K562, K562 blasts 
The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous… 
National Institutes of Health

Papers overview

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Highly Cited
1986
Highly Cited
1986
Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide.
The role of glutathione (GSH) as a determinant of cellular sensitivity to the cytotoxic and DNA-damaging effects of… 
Highly Cited
1986
Highly Cited
1986
Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus
The first detectable step in the degradation of human H4 histone mRNA occurs at the 3' terminus in a cell-free mRNA decay system… 
Highly Cited
1985
Highly Cited
1985
Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding.
Lipoxin A (5,6,15L-trihydroxy-7,9,11,13-eicosatetraenoic acid) and lipoxin B (5D,14,15-trihydroxy-6,8,10,12-eicosatetraenoic acid… 
Highly Cited
1985
Highly Cited
1985
T3 monoclonal antibody activation of nonspecific cytolysis: a mechanism of CTL inhibition.
The T3 antigen is expressed on all cytotoxic T lymphocytes (CTL). Monoclonal antibodies (MAb) to the T3 antigen previously have… 
Highly Cited
1984
Highly Cited
1984
Characteristics of human NK clones: target specificity and phenotype.
Clones derived from purified human large granular lymphocytes (LGL) of three different donors were expanded in culture medium… 
Highly Cited
1984
Highly Cited
1984
In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and "anomalous" killer cells.
The activation of human peripheral blood mononuclear cells (PBM) in culture leads to the generation of nonspecific killer cells… 
Highly Cited
1983
Highly Cited
1983
Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function
The present studies were carried out to identify surface molecules involved in the cytotoxic effector function of a human natural… 
Highly Cited
1983
Highly Cited
1983
Studies on the mechanism of the human natural killer cell lethal hit: analysis of the mechanism of protease inhibition of the lethal hit.
The terminal killer cell-independent lysis (KCIL) stage of the human natural killer (NK) lethal hit is blocked by the protease… 
Highly Cited
1982
Highly Cited
1982
Endogenous and interferon-augmented natural killer cell activity of human peripheral blood mononuclear cells in vitro. Studies of patients with multiple sclerosis, systemic lupus erythematosus or…
Peripheral blood mononuclear cells (PBMC) of normal human donors are spontaneously cytotoxic for certain tumour-derived and virus… 
Highly Cited
1978
Highly Cited
1978
Expression of human T-lymphocyte antigens by natural killer cells.
Rabbit antisera against human T-lymphocyte and B-lymphocyte antigens (anti-HTLA and anti-HBLA, respectively) were used to…