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Safety of high-dose nicotinamide: a review
Experience to date suggests that the ratio of risk to benefit of long-term nicotinamide treatment would be highly favourable, should the drug prove efficacious in diabetes prevention, and high-dose Nicotinamide should still be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged. Expand
Cytotoxicity, DNA cross-linking, and single strand breaks induced by activated cyclophosphamide and acrolein in human leukemia cells.
The demonstration of acrolein-induced single strand breaks following exposure to activated CP is a novel finding and suggests that acrole in may have a role in the cytotoxicity of CP. Expand
Ethanol pharmacokinetics in lactating women.
- V. A. da-Silva, L. R. Malheiros, A. R. Moraes-Santos, M. A. Barzano, A. Mclean
- Brazilian journal of medical and biological…
- 1 October 1993
The results indicate the importance of lactation for ethanol pharmacokinetics and raise questions about the pharmacokinetic effects of other drugs ingested by lactating women. Expand
Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.
An improved method for production of Cirrhosis of the liver in rats is described, which doubles the yield of cirrhotic animals and halves the time taken for their production, in comparison with CCl4 alone. Expand
The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve.
- P. Fitzharris, A. Mclean, R. G. Sparks, B. Weatherley, R. D. White, R. Wootton
- Chemistry, Medicine
- British journal of clinical pharmacology
- 1 April 1985
BW12C, a potent left-shifting anti-sickling compound in vitro, was administered to normal healthy male Caucasian volunteers and Pharmacokinetic measurements indicated uptake into erythrocytes, low levels in plasma and a volume of distribution not appreciably greater than the blood volume. Expand
The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine.
Modified methods for measurement of cytochrome P-450 content of liver homogenates, and of formaldehyde produced in demethylation reactions are described and it is suggested that the amount of toxic metabolite is more important than the rate at which it is formed. Expand
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Addition of methionine to the oral paracetamol dose protects against death and liver injury, and it is suggested that this may be a useful technique for making par acetamol safe against the danger of overdose. Expand
Cellular injury and carcinogenesis. The effect of a protein-free high-carbohydrate diet on the metabolism of dimethylnitrosamine in the rat.
In rats fed on a protein-free diet the incidence of kidney tumours produced by a single dose of dimethylnitrosamine is increased, and the methylation by dimethylNitrosamine of guanine in kidney nucleic acids of these rats was three times that in the rats feeding on a normal diet. Expand
Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.
It is suggested that phenobarbitone induces liver hydroxylation enzymes that metabolise aflatoxins to noncarcinogenic products and reduces the malignant characteristics of the tumours. Expand