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Neurotoxicity of a prion protein fragment
It is reported here that neuronal death results from chronic exposure of primary rat hippocampal cultures to micromolar concentrations of a peptide corresponding to residues 106–126 of the amino-acid sequence deduced from human PrP complementary DNA.
Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
- M. Fratelli, H. Demol, P. Ghezzi
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 19 March 2002
It is suggested that enolase and cyclophilin are heavily glutathionylated under basal conditions and might be a common mechanism for the global regulation of protein functions.
Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein
- C. Balducci, M. Beeg, G. Forloni
- Biology, PsychologyProceedings of the National Academy of Sciences
- 19 January 2010
It is reported that, in mice, acute intracerebroventricular injections of synthetic Aβ1–42 oligomers impaired consolidation of the long-term recognition memory, whereas mature Aβ 1–42 fibrils and freshly dissolved peptide did not, and it was confirmed that A β1– 42 oligomers interact with PrPC, with nanomolar affinity.
Glutathionylation of human thioredoxin: A possible crosstalk between the glutathione and thioredoxin systems
- Simona Casagrande, V. Bonetto, P. Ghezzi
- BiologyProceedings of the National Academy of Sciences…
- 15 July 2002
The intracellular glutathione/glutathione disulfide ratio, an indicator of the redox state of the cell, can regulate Trx functions reversibly through thiol-disulfide exchange reactions, suggesting a process of autoactivation due to the ability of Trx to de-glutATHionylate itself.
Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3
- B. Bottazzi, V. Vouret-Craviari, A. Mantovani
- BiologyThe Journal of Biological Chemistry
- 26 December 1997
The capacity to bind C1q, mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in response to interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity.
A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis
An APP mutation that causes disease only in the homozygous state, whereas heterozygous carriers were unaffected, consistent with a recessive Mendelian trait of inheritance is found, with implications for genetic screening and the potential treatment of Alzheimer's disease.
CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid
It is found that CtBP/BARS uses acyl-CoA to selectively catalyse the acylation of lysophosphatidic acid to phosphatidics acid both in pure lipidic systems and in Golgi membranes, and that this reaction is essential for fission.
Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.
Mptx3 showed a distinct pattern of in vivo expression indicative of a significant role in cardiovascular and inflammatory pathology and was induced by bacterial lipopolysaccharide in vivo in a variety of organs and in the vascular endothelium of skeletal muscle and heart.
Evaluation of Quinacrine Treatment for Prion Diseases
Despite its ability to cross the blood-brain barrier, the use of quinacrine for the treatment of CJD is questionable, at least as a monotherapy, and the multistep experimental approach employed here could be used to test new therapeutic regimes before their use in human trials.
Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins
The beneficial effects of statins on the reduction of cardiovascular events has been partly attributed to their anti-inflammatory properties. In the complex of the different pathogenetic events…