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Juvenile Myelomonocytic Leukemia

Known as: Leukemia, Myelomonocytic, Juvenile [Disease/Finding], JMML, Juvenile Chronic Myelogenous Leukemia 
A myelodysplastic/myeloproliferative neoplasm of childhood that is characterized by proliferation principally of the granulocytic and monocytic… 
National Institutes of Health

Related topics

Related topics

33 relations
AnemiaAutosomal dominant inheritanceBone MarrowBone marrow stem cell

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the… 
Highly Cited
2007
Highly Cited
2007
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and… 
Highly Cited
2004
Highly Cited
2004
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia
The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for normal development and is an essential… 
Highly Cited
1999
Highly Cited
1999
The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia
The fusion gene Cbfb - MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia 
Review
1998
Review
1998
Differentiating juvenile myelomonocytic leukemia from infectious disease.
To The Editor: Two recent articles in BLOOD 1,2 review the findings and outcome of juvenile myelomonocytic leukemia (JMML). Both… 
Review
1992
Review
1992
Retinoids in cancer therapy.
PURPOSE Recent reports of the dramatic antitumor effect of all-trans retinoic acid (RA) in patients with acute promyelocytic… 
Highly Cited
1992
Highly Cited
1992
Transplantation of umbilical cord blood after myeloablative therapy: analysis of engraftment.
The possibility that umbilical cord and placental blood from an HLA-identical sibling might produce stable donor-derived… 
Highly Cited
1991
Highly Cited
1991
Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors.
Juvenile chronic myelogenous leukemia (JCML) is a good model for the study of myeloproliferation because JCML hematopoietic… 
Highly Cited
1985
Highly Cited
1985
Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene
Interleukin-3 (multi-CSF) is a multilineage haematopoietic growth regulator that initiates the proliferation and differentiation… 
Highly Cited
1984
Highly Cited
1984
Human large granular lymphocytes are potent producers of interleukin-1
Natural killer (NK) activity1 against tumour and virus-infected target cells is shown by a subpopulation of peripheral blood… 
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