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Developmentally Essential Protein Flightless I Is a Nuclear Receptor Coactivator with Actin Binding Activity
TLDR
Yeast two-hybrid screen for proteins that bind CARM1 identified the protein Flightless I (Fli-I), which has essential roles in Drosophila and mouse development and suggests that Fli-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivATOR complexes containing actin or actin-like proteins. Expand
Recombinant human interleukin 5 is a selective activator of human eosinophil function
Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophilExpand
The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases.
TLDR
The results suggest that PI 3-kinase and the small GTPases, Ras, RhoA and Cdc42 may be part of a common functional pathway involved in Fliih-mediated cytoskeletal regulation. Expand
SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with
TLDR
SOLH is a candidate gene for CATM (hereditary cataracts with microphthalmia), which maps in this region, and northern analysis of human tissues revealed a SOLH transcript of approximately 5 kb that was strongest in human brain. Expand
The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and
TLDR
The structure of the maternally expressed flightless-I protein suggests that it may play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components. Expand
Fliih, a Gelsolin-Related Cytoskeletal Regulator Essential for Early Mammalian Embryonic Development
TLDR
A transgenic mouse carrying the complete human FLII gene is constructed and shown that the FLII transgene is capable of rescuing the embryonic lethality of the homozygous targeted Fliih mutation. Expand
The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis.
TLDR
The transcription unit of the sluggish-A gene is localized to a 14.7-kb region at the base of the X chromosome and the predicted protein product has significant sequence similarity to Saccharomyces cerevisiae proline oxidase (EC 1.5.99). Expand
Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene
TLDR
It is reported here that the constitutive synthesis of IL-3 by the WEHI-3B cell line is due to the insertion of an endogenous retrovirus-like element close to the 5′ end of the gene. Expand
Nucleotide sequence coding for the respiratory NADH dehydrogenase of Escherichia coli. UUG initiation codon.
TLDR
The nucleotide sequence of the structural gene coding for the respiratory NADH dehydrogenase of Escherichia coli has been determined by the chain-termination method and the product made in vivo was found to have threonine as its N-terminal residue, indicating that the initiating N-formylmethionine had been removed by post-translational processing. Expand
Sex hormones and dexamethasone modulate interleukin-5 gene expression in T lymphocytes
TLDR
The results show that sex hormones have the potential to regulate cytokine gene expression in cells possessing the appropriate steroid receptors. Expand
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