PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.


Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2… (More)
DOI: 10.1182/blood-2006-07-028829

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