Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.

@article{Loh2009MutationsIC,
  title={Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.},
  author={Mignon L Loh and Debbie S Sakai and Christian Flotho and Michelle W. Kang and Manfred Fliegauf and Sophie L. Archambeault and Charles G Mullighan and Leslie Y Chen and Eva Bergstraesser and Carlos E Bueso-Ramos and Peter D Emanuel and Henrik Hasle and Jean-Pierre Issa and Marry M van den Heuvel-Eibrink and Franco Locatelli and Jan Star{\'y} and Monica Trebo and Marcin W Wlodarski and Marco Zecca and Kevin Michael Shannon and Charlotte Marie Niemeyer},
  journal={Blood},
  year={2009},
  volume={114 9},
  pages={
          1859-63
        }
}
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Seventy-five percent of patients harbor mutations in the NF1, NRAS, KRAS, or PTPN11 genes, which encode components of Ras signaling networks. Using single nucleotide polymorphism arrays, we identified a region of 11q isodisomy that contains the CBL gene in several JMML samples, and… CONTINUE READING
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